Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders.

IF 5.3 2区医学

Current Osteoporosis Reports Pub Date : 2022-10-01 Epub Date: 2022-07-26 DOI:10.1007/s11914-022-00739-6

Alessia S Cento, Massimiliano Leigheb, Giuseppina Caretti, Fabio Penna

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Abstract

Purpose of review: The incidence of musculoskeletal disorders affecting bones, joints, and muscles is dramatically increasing in parallel with the increased longevity of the worldwide population, severely impacting on the individual's quality of life and on the healthcare costs. Inactivity and sedentary lifestyle are nowadays considered the main drivers of age-associated musculoskeletal disorders and exercise may counteract such alterations also in other bone- and muscle-centered disorders. This review aims at clarifying the potential use of exercise training to improve musculoskeletal health.

Recent findings: Both the skeletal muscle and the bone are involved in a complex crosstalk determining, in part through tissue-specific and inflammatory/immune released factors, the occurrence of musculoskeletal disorders. Exercise is able to modulate the levels of those molecules and several associated molecular pathways. Evidence from preclinical and clinical trials supports the adoption of exercise and the future use of exercise mimicking drugs will optimize the care of individuals with musculoskeletal disorders.

Abstract Image

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治疗肌肉骨骼疾病的运动和运动模拟疗法。

综述的目的：随着全球人口寿命的延长，影响骨骼、关节和肌肉的肌肉骨骼疾病的发病率也在急剧上升，严重影响了个人的生活质量和医疗成本。如今，不运动和久坐不动的生活方式被认为是与年龄相关的肌肉骨骼疾病的主要诱因，而运动可以抵消这种变化，也可以抵消其他以骨骼和肌肉为中心的疾病。本综述旨在阐明运动训练在改善肌肉骨骼健康方面的潜在作用：最新研究结果：骨骼肌和骨骼之间存在着复杂的相互影响关系，在一定程度上通过组织特异性因素和炎症/免疫释放因素决定着肌肉骨骼疾病的发生。运动能够调节这些分子的水平和一些相关的分子通路。临床前和临床试验的证据支持采用运动疗法，未来使用运动模拟药物将优化对肌肉骨骼疾病患者的治疗。

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来源期刊

Current Osteoporosis Reports ENDOCRINOLOGY & METABOLISM-

CiteScore

8.40

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.