{"title":"Association of vitamin D receptor polymorphisms with vitamin D and calcium levels in Turkish multiple sclerosis patients.","authors":"Aylin Elkama, Gürdal Orhan, Bensu Karahalil","doi":"10.2217/nmt-2022-0005","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> The present study was conducted to assess the impact of gene (vitamin D receptor [VDR] polymorphisms) - environment (serum vitamin D and calcium levels) interaction on multiple sclerosis (MS) risk. <b>Materials & methods:</b> <i>FokI</i>, <i>BsmI</i>, <i>TaqI</i> and <i>ApaI</i> genotyping were performed in 149 MS patients and 127 controls. We measured serum vitamin D and calcium levels. <b>Results:</b> No significant difference between VDR polymorphisms and MS risk was detected. In patients with <i>FokI ff</i>, <i>BsmI Bb, TaqI Tt</i> and <i>ApaI AA</i> genotypes, vitamin D levels were statistically higher. Serum calcium levels were significantly lower in patients with <i>FokI FF</i>, <i>Ff</i>, all <i>BsmI</i> and <i>TaqI</i> genotypes and <i>ApaI AA</i> and <i>Aa</i> genotypes. <b>Conclusion:</b> No significant association was found between VDR polymorphisms with MS risk.</p>","PeriodicalId":19114,"journal":{"name":"Neurodegenerative disease management","volume":" ","pages":"323-331"},"PeriodicalIF":2.3000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurodegenerative disease management","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/nmt-2022-0005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/7/18 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 2
Abstract
Aim: The present study was conducted to assess the impact of gene (vitamin D receptor [VDR] polymorphisms) - environment (serum vitamin D and calcium levels) interaction on multiple sclerosis (MS) risk. Materials & methods:FokI, BsmI, TaqI and ApaI genotyping were performed in 149 MS patients and 127 controls. We measured serum vitamin D and calcium levels. Results: No significant difference between VDR polymorphisms and MS risk was detected. In patients with FokI ff, BsmI Bb, TaqI Tt and ApaI AA genotypes, vitamin D levels were statistically higher. Serum calcium levels were significantly lower in patients with FokI FF, Ff, all BsmI and TaqI genotypes and ApaI AA and Aa genotypes. Conclusion: No significant association was found between VDR polymorphisms with MS risk.
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