Raman studies of the adipose tissue: Current state-of-art and future perspectives in diagnostics

IF 14 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in lipid research Pub Date : 2022-07-01 DOI:10.1016/j.plipres.2022.101183

Krzysztof Czamara , Zuzanna Majka , Ewa Stanek , Natalia Hachlica , Agnieszka Kaczor

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引用次数: 2

Abstract

The last decades revealed that the adipose tissue shows an unexplored therapeutic potential. In particular, targeting the perivascular adipose tissue (PVAT), that surrounds blood vessels, can prevent cardiovascular pathologies and browning of the adipose tissue can become an effective strategy against obesity. Therefore, new analytical tools are necessary to analyze this tissue. This review reports on the recent developments of various Raman-based techniques for the identification and quantification of the adipose tissue compared to conventional analytical methods. In particular, the emphasis is on analysis of PVAT, investigation of pathological changes of the adipose tissue in model systems and possibilities for its characterization in the clinical context. Overall, the review critically discusses the potential and limitations of Raman techniques in adipose tissue-targeted diagnostics and possible future anti-obesity therapies.

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脂肪组织的拉曼研究:诊断的当前状态和未来前景

过去几十年的研究表明，脂肪组织显示出一种尚未开发的治疗潜力。特别是针对血管周围的血管周围脂肪组织(PVAT)，可以预防心血管疾病，脂肪组织的褐色化可以成为对抗肥胖的有效策略。因此，需要新的分析工具来分析这种组织。本文综述了与传统分析方法相比，各种基于拉曼的脂肪组织鉴定和定量技术的最新进展。特别地，重点是分析PVAT，研究模型系统中脂肪组织的病理变化及其在临床环境中表征的可能性。总之，这篇综述批判性地讨论了拉曼技术在脂肪组织靶向诊断和未来可能的抗肥胖治疗中的潜力和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in lipid research 生物-生化与分子生物学

CiteScore

24.50

自引率

2.20%

发文量

审稿时长

14.6 weeks

期刊介绍： The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.