The Repeatable Battery for the Assessment of Neuropsychological Status, While Useful for Measuring Cognitive Changes in Manifest Huntington Disease, May Show Limited Utility in Premanifest Disease.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Andrea I Mustafa, Jody Corey-Bloom, Ilex Beltran-Najera, Chase Snell, Jordan Castleton, Haileigh Smith, Paul E Gilbert
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Abstract

Background: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is a brief, standardized neuropsychological test that assesses several areas of cognitive function. Recent studies, although sparse, have examined the use of the RBANS to detect cognitive deficits in individuals with manifest Huntington disease (HD); however, no studies have investigated its utility to detect cognitive deficits in individuals with premanifest HD (PreHD), where cognitive symptoms are thought to be more subtle.

Objective: To assess cognitive deficits in individuals with HD, particularly in individuals with PreHD, using an easily administered, brief but comprehensive, neuropsychological test.

Method: We administered the RBANS to 31 individuals with HD, 29 individuals with PreHD, and 22 healthy controls (HC) at an academic HD clinical research center and collected RBANS Total, Index, and subtest scores for group comparisons.

Results: The HD group had significantly lower RBANS Total, Index, and subtest scores than the HC. The PreHD group had significantly lower RBANS Total scores and Coding subtest scores than the HC, but no other significant group differences were identified.

Conclusion: Our results substantiate previous findings of significant impairment on the RBANS in individuals with HD. In addition, we are the first to demonstrate that, although the RBANS can identify deficits in psychomotor speed and information processing in individuals with PreHD, it does not appear to have the ability to detect impairment in any additional cognitive domains in individuals with PreHD.

用于评估神经心理状态的可重复电池,虽然可用于测量显性亨廷顿舞蹈症的认知变化,但可能在显性前疾病中显示出有限的效用。
背景:用于评估神经心理状态的可重复电池(RBANS)是一种简短、标准化的神经心理学测试,用于评估认知功能的几个领域。最近的研究虽然很少,但已经检查了使用RBANS来检测明显亨廷顿舞蹈症(HD)患者的认知缺陷;然而,没有研究调查其在检测早产HD(PreHD)患者认知缺陷方面的效用,因为认知症状被认为更为微妙。目的:使用一种简单、简短但全面的神经心理学测试来评估HD患者的认知缺陷,特别是PreHD患者。方法:我们在一家学术性HD临床研究中心对31名HD患者、29名PreHD患者和22名健康对照组(HC)进行了RBANS,并收集了RBANS总分、指数和分测验得分进行组间比较。结果:HD组的RBANS总分、指数和亚测验得分均显著低于HC组。PreHD组的RBANS总分和编码子测验得分显著低于HC组,但没有发现其他显著的组间差异。结论:我们的研究结果证实了先前关于HD患者RBANS显著受损的研究结果。此外,我们率先证明,尽管RBANS可以识别患有PreHD的个体在心理运动速度和信息处理方面的缺陷,但它似乎没有能力检测患有PreHD个体在任何其他认知领域的损伤。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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