The Repeatable Battery for the Assessment of Neuropsychological Status, While Useful for Measuring Cognitive Changes in Manifest Huntington Disease, May Show Limited Utility in Premanifest Disease.

IF 1.3 4区 医学 Q4 BEHAVIORAL SCIENCES
Andrea I Mustafa, Jody Corey-Bloom, Ilex Beltran-Najera, Chase Snell, Jordan Castleton, Haileigh Smith, Paul E Gilbert
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引用次数: 0

Abstract

Background: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is a brief, standardized neuropsychological test that assesses several areas of cognitive function. Recent studies, although sparse, have examined the use of the RBANS to detect cognitive deficits in individuals with manifest Huntington disease (HD); however, no studies have investigated its utility to detect cognitive deficits in individuals with premanifest HD (PreHD), where cognitive symptoms are thought to be more subtle.

Objective: To assess cognitive deficits in individuals with HD, particularly in individuals with PreHD, using an easily administered, brief but comprehensive, neuropsychological test.

Method: We administered the RBANS to 31 individuals with HD, 29 individuals with PreHD, and 22 healthy controls (HC) at an academic HD clinical research center and collected RBANS Total, Index, and subtest scores for group comparisons.

Results: The HD group had significantly lower RBANS Total, Index, and subtest scores than the HC. The PreHD group had significantly lower RBANS Total scores and Coding subtest scores than the HC, but no other significant group differences were identified.

Conclusion: Our results substantiate previous findings of significant impairment on the RBANS in individuals with HD. In addition, we are the first to demonstrate that, although the RBANS can identify deficits in psychomotor speed and information processing in individuals with PreHD, it does not appear to have the ability to detect impairment in any additional cognitive domains in individuals with PreHD.

用于评估神经心理状态的可重复电池,虽然可用于测量显性亨廷顿舞蹈症的认知变化,但可能在显性前疾病中显示出有限的效用。
背景:用于评估神经心理状态的可重复电池(RBANS)是一种简短、标准化的神经心理学测试,用于评估认知功能的几个领域。最近的研究虽然很少,但已经检查了使用RBANS来检测明显亨廷顿舞蹈症(HD)患者的认知缺陷;然而,没有研究调查其在检测早产HD(PreHD)患者认知缺陷方面的效用,因为认知症状被认为更为微妙。目的:使用一种简单、简短但全面的神经心理学测试来评估HD患者的认知缺陷,特别是PreHD患者。方法:我们在一家学术性HD临床研究中心对31名HD患者、29名PreHD患者和22名健康对照组(HC)进行了RBANS,并收集了RBANS总分、指数和分测验得分进行组间比较。结果:HD组的RBANS总分、指数和亚测验得分均显著低于HC组。PreHD组的RBANS总分和编码子测验得分显著低于HC组,但没有发现其他显著的组间差异。结论:我们的研究结果证实了先前关于HD患者RBANS显著受损的研究结果。此外,我们率先证明,尽管RBANS可以识别患有PreHD的个体在心理运动速度和信息处理方面的缺陷,但它似乎没有能力检测患有PreHD个体在任何其他认知领域的损伤。
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来源期刊
CiteScore
2.40
自引率
7.10%
发文量
68
审稿时长
>12 weeks
期刊介绍: Cognitive and Behavioral Neurology (CBN) is a forum for advances in the neurologic understanding and possible treatment of human disorders that affect thinking, learning, memory, communication, and behavior. As an incubator for innovations in these fields, CBN helps transform theory into practice. The journal serves clinical research, patient care, education, and professional advancement. The journal welcomes contributions from neurology, cognitive neuroscience, neuropsychology, neuropsychiatry, and other relevant fields. The editors particularly encourage review articles (including reviews of clinical practice), experimental and observational case reports, instructional articles for interested students and professionals in other fields, and innovative articles that do not fit neatly into any category. Also welcome are therapeutic trials and other experimental and observational studies, brief reports, first-person accounts of neurologic experiences, position papers, hypotheses, opinion papers, commentaries, historical perspectives, and book reviews.
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