Overview of COVID-19-Associated Invasive Fungal Infection.

IF 2.3 Q3 INFECTIOUS DISEASES

Current Fungal Infection Reports Pub Date : 2022-01-01 Epub Date: 2022-07-11 DOI:10.1007/s12281-022-00434-0

Akira A Shishido, Minu Mathew, John W Baddley

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Abstract

Purpose of review: Invasive fungal infections are a complication of COVID-19 disease. This article reviews literature characterizing invasive fungal infections associated with COVID-19.

Recent findings: Multiple invasive fungal infections including aspergillosis, candidiasis, pneumocystosis, other non-Aspergillus molds, and endemic fungi have been reported in patients with COVID-19. Risk factors for COVID-19-associated fungal disease include underlying lung disease, diabetes, steroid or immunomodulator use, leukopenia, and malignancy. COVID-19-associated pulmonary aspergillosis (CAPA) and COVID-19-associated mucormycosis (CAM) are the most common fungal infections described. However, there is variability in the reported incidences related to use of differing diagnostic algorithms.

Summary: Fungal pathogens are important cause of infection in patients with COVID-19, and the diagnostic strategies continue to evolve. Mortality in these patients is increased, and providers should operate with a high index of suspicion. Further studies will be required to elucidate the associations and pathogenesis of these diseases and best management and prevention strategies.

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与 COVID-19 相关的侵袭性真菌感染概述。

审查目的：侵袭性真菌感染是 COVID-19 疾病的并发症之一。本文回顾了与 COVID-19 相关的侵袭性真菌感染的文献：有报道称，COVID-19 患者中存在多种侵袭性真菌感染，包括曲霉菌病、念珠菌病、肺囊肿病、其他非曲霉菌霉菌和地方性真菌。COVID-19 相关真菌病的风险因素包括潜在的肺部疾病、糖尿病、使用类固醇或免疫调节剂、白细胞减少症和恶性肿瘤。COVID-19相关肺曲霉菌病（CAPA）和COVID-19相关粘孢子菌病（CAM）是最常见的真菌感染。然而，由于使用的诊断算法不同，报告的发病率也存在差异：真菌病原体是COVID-19患者感染的重要原因，诊断策略也在不断发展。这些患者的死亡率会升高，因此医疗人员在操作时应高度怀疑。要阐明这些疾病的关联和发病机制以及最佳管理和预防策略，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Fungal Infection Reports INFECTIOUS DISEASES-

CiteScore

3.10

自引率

7.10%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of fungal infections. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as advances in diagnosis, current and emerging management approaches, and genomics and pathogenesis. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. Commentaries from well-known figures in the field are also provided, and an international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research.