Effect of Castor Oil on Cervical Ripening and Labor Induction: a systematic review and meta-analysis.

IF 1.2 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Pharmacopuncture Pub Date : 2022-06-30 DOI:10.3831/KPI.2022.25.2.71

Maryam Moradi, Azin Niazi, Ehsan Mazloumi, Violeta Lopez

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引用次数: 2

Abstract

Objectives: Post-term pregnancy is a condition associated with increased maternal and fetal complications. Administration of castor oil causes cervical stimulation by increasing the production of prostaglandins. We examined the effects of castor oil on cervical ripening and labor induction through a systematic review and meta-analysis.

Methods: The search process was performed to obtain relevant articles from databases including Pubmed, Cochrane library, Scopus, Science direct, SID, Iran Medex, and Google Scholar using the English keywords of cervical ripening, post-term, castor oil, labor induction, Bishop score, and pregnancy considering all possible combinations without time constraints and their Persian equivalents from national databases.

Results: A total of eight related articles from the 19 primary studies were extracted and systematically reviewed. According to a cumulative chart, the difference in the post-intervention Bishop score was statistically significant (standard mean difference [SMD] 1.64, 95% confidence interval [CI] 1.67-2.11, p = 0.001), indicating an effect of castor oil on increasing the Bishop score. In addition, the difference in labor induction was statistically significant after the intervention (odds ratio 11.67, 95% CI 3.34-40.81, p = 0.001), indicating an effect of castor oil on increasing the odds ratio of labor induction (experience of vaginal delivery).

Conclusion: This meta-analysis showed that oral administration of castor oil is effective for cervical ripening and labor induction. Midwives should closely monitor pregnant women with prolonged labor and collaborate with obstetricians to employ castor oil as a safe intervention to induce cervical ripening and labor to prevent undue caesarean surgery.

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蓖麻油对宫颈成熟和引产的影响:一项系统综述和荟萃分析。

目的:足月妊娠是一种与母体和胎儿并发症增加相关的疾病。服用蓖麻油会增加前列腺素的分泌，从而刺激颈椎。我们通过系统回顾和荟萃分析研究了蓖麻油对宫颈成熟和引产的影响。方法:从Pubmed、Cochrane library、Scopus、Science direct、SID、Iran Medex和Google Scholar等数据库中检索相关文章，检索关键词为宫颈成熟、产后、蓖麻油、引产、Bishop评分和妊娠，考虑所有可能的组合，不考虑时间限制，并从国家数据库中检索对应的波斯语。结果:从19项主要研究中共提取8篇相关文章并进行系统综述。从累积图来看，干预后Bishop评分差异有统计学意义(标准均值差[SMD] 1.64, 95%可信区间[CI] 1.67 ~ 2.11, p = 0.001)，表明蓖麻油对提高Bishop评分有作用。此外，干预后引产的差异有统计学意义(优势比11.67,95% CI 3.34-40.81, p = 0.001)，表明蓖麻油对提高引产(阴道分娩经验)的优势比有作用。结论:本荟萃分析显示，口服蓖麻油对宫颈成熟和引产有效。助产士应密切监测长时间分娩的孕妇，并与产科医生合作，使用蓖麻油作为安全干预措施，以诱导宫颈成熟和分娩，以防止过度剖腹产手术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmacopuncture INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

2.10

自引率

7.10%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Pharmacopuncture covers a wide range of basic and clinical science research relevant to all aspects of the biotechnology of integrated approaches using both pharmacology and acupuncture therapeutics, including research involving pharmacology, acupuncture studies and pharmacopuncture studies. The subjects are mainly divided into three categories: pharmacology (applied phytomedicine, plant sciences, pharmacology, toxicology, medicinal plants, traditional medicines, herbal medicine, Sasang constitutional medicine, herbal formulae, foods, agricultural technologies, naturopathy, etc.), acupuncture (acupressure, electroacupuncture, laser acupuncture, moxibustion, cupping, etc.), and pharmacopuncture (aqua-acupuncture, meridian pharmacopuncture, eight-principles pharmacopuncture, animal-based pharmacopuncture, mountain ginseng pharmacopuncture, bee venom therapy, needle embedding therapy, implant therapy, etc.). Other categories include chuna treatment, veterinary acupuncture and related animal studies, alternative medicines for treating cancer and cancer-related symptoms, etc. Broader topical coverage on the effects of acupuncture, the medical plants used in traditional and alternative medicine, pharmacological action and other related modalities, such as anthroposophy, homeopathy, ayurveda, bioelectromagnetic therapy, chiropractic, neural therapy and meditation, can be considered to be within the journal’s scope if based on acupoints and meridians. Submissions of original articles, review articles, systematic reviews, case reports, brief reports, opinions, commentaries, medical lectures, letters to the editor, photo-essays, technical notes, and book reviews are encouraged. Providing free access to the full text of all current and archived articles on its website (www.journal.ac), also searchable through a Google Scholar search.