Changes in ocular pulse amplitude and posterior ocular structure parameters in type 1 diabetic children without diabetic retinopathy.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2022-07-07 eCollection Date: 2022-01-01 DOI:10.1177/25158414221101710

Abdulvahit Asik, Semih Bolu, Ilke Direkci, Emre Aydemir, Gozde Aksoy Aydemir

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引用次数: 1

Abstract

Background: It is important to determine changes in posterior ocular structures in the early period before retinopathy develops in pediatric patients with type 1 diabetes mellitus (DM).

Objective: To evaluate inner plexiform layer (IPL), ganglion cell layer (GCL), and retinal nerve fiber layer (RNFL) thicknesses, as well as the relationship between choroidal thickness (CT) and ocular pulse amplitude (OPA) in type 1 diabetic children without diabetic retinopathy (DR).

Design: A prospective observational study.

Methods: Group 1 (n = 44) consisted of pediatric patients with type 1 DM without DR, and Group 2 (n = 65) of pediatric control subjects. Both intraocular pressure (IOP) and OPA were measured using a dynamic contour tonometer. CT, IPL, GCL, and RNFL were all measured using spectral domain optical coherence tomography (OCT).

Results: The mean IOP and OPA values were 16.67 ± 2.34 and 1.85 ± 0.34, respectively, in group 1, and 15.14 ± 2.17 and 1.65 ± 0.25 in Group 2 (p = 0.001 for both). The mean subfoveal CT value was 294.30 ± 67.61 μm in group 1 and 394.42 ± 69.65 μm in Group 2 (p < 0.001). The mean GCL and RNFL values were 1.09 ± 0.11 and 96.46 ± 11.69, respectively, in group 1, and 1.14 ± 0.09 and 101.73 ± 9.33 in Group 2 (p = 0.005 and p = 0.008, respectively).

Conclusions: IOP and OPA values were higher, and CT, GCL, and RNFL values were lower in children with type 1 DM during the early stages than in the healthy control group. These findings suggest that CT may be a marker of retinal involvement in children with type 1 DM without DR.

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无糖尿病视网膜病变的1型糖尿病儿童眼脉冲振幅和眼后结构参数的变化。

背景:在1型糖尿病(DM)患儿视网膜病变发生前早期确定后眼结构的变化是很重要的。目的:探讨无糖尿病视网膜病变(DR)的1型糖尿病患儿视网膜内丛状层(IPL)、神经节细胞层(GCL)、视网膜神经纤维层(RNFL)厚度及脉络膜厚度(CT)与眼脉冲幅值(OPA)的关系。设计:前瞻性观察性研究。方法:第一组(n = 44)为无DR的1型糖尿病患儿，第二组(n = 65)为儿童对照。眼压(IOP)和眼压(OPA)均采用动态轮廓眼压计测量。CT、IPL、GCL和RNFL均采用光谱域光学相干断层扫描(OCT)测量。结果:组1平均IOP为16.67±2.34,OPA为1.85±0.34;组2平均IOP为15.14±2.17,OPA为1.65±0.25 (p = 0.001)。1组和2组的平均CT值分别为294.30±67.61 μm和394.42±69.65 μm (p值分别为0.005和0.008)。结论:1型糖尿病患儿早期IOP、OPA值高于健康对照组，CT、GCL、RNFL值低于健康对照组。这些发现提示CT可能是无DR的1型糖尿病儿童视网膜受累的标志。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.