A Histochemical Analysis of Neurofibrillary Tangles in Olfactory Epithelium, a Study Based on an Autopsy Case of Juvenile Alzheimer's Disease.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2022-06-29 Epub Date: 2022-06-25 DOI:10.1267/ahc.22-00048
Shino Shimizu, Ichiro Tojima, Keigo Nakamura, Hideaki Kouzaki, Takeshi Kanesaka, Norihiro Ogawa, Yoshio Hashizume, Hiroyasu Akatsu, Akira Hori, Ikuo Tooyama, Takeshi Shimizu
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引用次数: 1

Abstract

The pathological changes of Alzheimer's disease (AD) begin 10-20 years before clinical onset, and it is therefore desirable to identify effective methods for early diagnosis. The nasal mucosa is a target tissue for measuring AD-related biomarkers because the olfactory nerve is the only cranial nerve that is exposed to the external environment. We describe an autopsy case of rapidly advanced juvenile AD (JAD), focusing on the olfactory system. The formation of senile plaques, neurofibrillary tangles (NFTs), and neuropil threads was examined in the temporal cortex, hippocampus, olfactory bulb, and olfactory and respiratory epithelia in the bilateral olfactory clefts. Neurodegenerative changes in the olfactory and respiratory epithelia and the pathological deposition of amyloid β42 (Aβ42) and phosphorylated tau were also examined. As a result, senile plaques, NFTs, and neuropil threads were found in the temporal cortex, hippocampus, and olfactory bulb. NFTs were also found in the olfactory epithelium. Degenerated olfactory cells and their axons stained positive for phosphorylated tau. Supporting cells in the degenerated olfactory epithelium stained positive for Aβ42. In conclusion, pathological biomarkers of AD were expressed in the degenerated olfactory epithelium of this JAD patient. This observation suggests that nasal samples may be useful for the diagnosis of AD.

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嗅觉上皮中神经原纤维缠结的组织化学分析,基于一例青少年阿尔茨海默病的尸检研究。
阿尔茨海默病(AD)的病理变化在临床发病前10-20年就开始了,因此需要找到有效的早期诊断方法。鼻黏膜是测量ad相关生物标志物的靶组织,因为嗅觉神经是唯一暴露于外部环境的颅神经。我们描述了一个快速晚期青少年AD (JAD)的尸检病例,重点是嗅觉系统。在双侧嗅裂的颞叶皮层、海马、嗅球、嗅上皮和呼吸上皮中检测老年斑、神经原纤维缠结(nft)和神经丝的形成。嗅觉和呼吸上皮的神经退行性改变以及淀粉样蛋白β42 (Aβ42)和磷酸化tau的病理沉积也被检查。结果,在颞叶皮层、海马体和嗅球中发现了老年斑、nft和神经丝。在嗅上皮中也发现了nft。退化的嗅觉细胞及其轴突磷酸化tau蛋白呈阳性。变性嗅上皮内的支持细胞a - β42染色阳性。综上所述,AD的病理生物标志物在该JAD患者退化的嗅上皮中表达。这一观察结果表明,鼻腔样本可能对阿尔茨海默病的诊断有用。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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