Effects of coronavirus disease 19 on the gastrointestinal tract and the potential impact on gastrointestinal toxicities during cancer treatment.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-09-01 DOI:10.1097/SPC.0000000000000604

Andrea M Stringer

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Abstract

Purpose of review: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has resulted in a global pandemic, with people with other conditions at greater risk of severe infection with intensified symptoms across multiple organ systems. Patients with cancer are at greater risk, and it is likely that those receiving treatment will experience greater incidence and severity of gastrointestinal toxicities, such as gastrointestinal mucositis, due to SARS-CoV-2 binding to angiotensin-converting enzyme (ACE)2 in the intestine.

Recent findings: Recent studies have shown that SARS-CoV-2 patients experience gastrointestinal toxicities, and SARS-CoV-2 has capacity to infect intestinal cells through binding to ACE2 expressed in the intestine. ACE2 has a key role in intestinal homeostasis, and as such there is a concern for the impact of SARS-CoV-2 binding to ACE2 in terms of the implications for cancer treatment-induced gastrointestinal toxicities.

Summary: SARS-CoV-2 is a high-risk infection for cancer patients receiving treatment. It is important to understand the mechanisms of intestinal infection with SARS-CoV-2 to determine the effect of SARS-CoV-2 infections on gastrointestinal toxicities, such as mucositis.

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冠状病毒19对胃肠道的影响及癌症治疗期间对胃肠道毒性的潜在影响

回顾目的:严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)已导致全球大流行，患有其他疾病的人发生严重感染的风险更大，并伴有多器官系统症状加剧。癌症患者的风险更大，而且由于SARS-CoV-2与肠道中的血管紧张素转换酶(ACE)2结合，接受治疗的患者可能会出现更大的胃肠道毒性，如胃肠道粘膜炎，发病率和严重程度也会更高。最新发现:最近的研究表明，SARS-CoV-2患者会出现胃肠道毒性，并且SARS-CoV-2具有通过与肠道中表达的ACE2结合感染肠细胞的能力。ACE2在肠道内稳态中起关键作用，因此，就癌症治疗诱导的胃肠道毒性而言，SARS-CoV-2与ACE2结合的影响值得关注。总结:SARS-CoV-2是接受治疗的癌症患者的高危感染。了解肠道感染SARS-CoV-2的机制对于确定SARS-CoV-2感染对胃肠道毒性(如粘膜炎)的影响至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.