Allogenic Umbilical Cord Tissue for Treatment of Knee Osteoarthritis.

IF 2.5 4区 医学 Q2 SPORT SCIENCES
Sports Medicine and Arthroscopy Review Pub Date : 2022-09-01 Epub Date: 2022-08-03 DOI:10.1097/JSA.0000000000000350
Ashim Gupta, Nicola Maffulli
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引用次数: 6

Abstract

Interest in use of perinatal allogenic tissues including clinical-grade minimally manipulated umbilical cord tissue-derived allograft formulations to treat knee osteoarthritis (OA) patients is increasing. Limited studies have characterized these formulations and evaluated their safety and efficacy in knee OA patients. We developed such formulation and reported the presence of growth factors, cytokines, hyaluronic acid, and exosomes. We reported that its administration is safe, and resulted in 50% pain reduction and improvement in knee injury and osteoarthritis outcome score (over 10%) and 36-item short form survey (25%). Another study reported no adverse events post injection of similar formulation and statistically significant ( P <0.001) improvement in visual analog scale and Western Ontario and McMaster Universities Osteoarthritis Index scores and reduction in medication usage in patients (77.8%). We also summarized the clinical trials registered on ClinicalTrials.gov utilizing umbilical cord tissue for knee OA treatment. In conclusion, available studies are preliminary but pave the way to higher level appropriately powered investigations, and these formulations should be considered as nonoperative alternative to manage knee OA.

同种异体脐带组织治疗膝骨关节炎。
使用围产期同种异体组织,包括临床级微创操作脐带组织来源的同种异体移植制剂治疗膝骨关节炎(OA)患者的兴趣正在增加。有限的研究描述了这些配方,并评估了它们在膝关节OA患者中的安全性和有效性。我们开发了这样的配方,并报道了生长因子、细胞因子、透明质酸和外泌体的存在。我们报道了它的使用是安全的,并导致50%的疼痛减轻和膝关节损伤和骨关节炎结局评分的改善(超过10%)和36项简短调查(25%)。另一项研究报告类似制剂注射后无不良事件,具有统计学意义(P
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Sports Medicine and Arthroscopy Review helps physicians digest the large volume of clinical literature in sports medicine and arthroscopy, identify the most important new developments, and apply new information effectively in clinical practice. Each issue is guest-edited by an acknowledged expert and focuses on a single topic or controversy. The Guest Editor invites the leading specialists on the topic to write review articles that highlight the most important advances. This unique format makes the journal more in-depth, authoritative, and practical than most publications in this field. The journal also includes dozens of full-color and black-and-white arthroscopic images and illustrations.
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