Association between Transcription Factor 7-Like 2 C/T Polymorphism and Diabetic Retinopathy Risk: A Meta-Analysis.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ophthalmic Research Pub Date : 2023-01-01 Epub Date: 2022-07-08 DOI:10.1159/000525803

Yong Zhang, Gui-Ping Pan, Jun-Wei Cai, Yu-Ming Niu, Long-Chuan Xie

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引用次数: 2

Abstract

Background: Previous studies have suggested a close association between transcription factor 7-like 2 (TCF7L2) polymorphisms and diabetic retinopathy (DR) susceptibility. However, the published results were inconsistent. This meta-analysis was conducted to review and examine the relationship between TCF7L2 rs7903146 C/T polymorphism and DR risk.

Materials and methods: Online databases were searched, and the related studies were identified in this meta-analysis. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to examine the statistical power. Moreover, heterogeneity test, sensitivity accumulative analysis, and publication bias were conducted to measure the statistical effect.

Result: 6 studies involving 12,982 subjects were included in this meta-analysis to assess the association between rs7903146 C/T polymorphism and DR susceptibility. The synthetic results indicated that the mutation of rs7903146 C/T polymorphism maybe accompanied with an increased risk for DR (T vs. C: OR = 1.26, 95% CI = 1.00-1.60, p = 0.05, I2 = 83.5%; TT vs. CC: OR = 1.79, 95% CI = 1.12-2.86, p = 0.02, I2 = 80.2%; TT vs. CC + CT: OR = 1.62, 95% CI = 1.38-1.92, p < 0.01, I2 = 32.3%). Moreover, the subgroup analysis also demonstrated an increasing risk for DR with T mutations in Caucasian descendants.

Conclusion: The current evidences of meta-analysis suggested that the TCF7L2 rs7903146 C/T polymorphism might play an important role in DR susceptibility.

查看原文本刊更多论文

转录因子 7-Like 2 C/T 多态性与糖尿病视网膜病变风险的关系：一项 Meta 分析。

背景：以往的研究表明，转录因子 7-like 2（TCF7L2）多态性与糖尿病视网膜病变（DR）的易感性密切相关。然而，已发表的结果并不一致。本荟萃分析旨在回顾和研究 TCF7L2 rs7903146 C/T 多态性与 DR 风险之间的关系：检索在线数据库，并在荟萃分析中确定相关研究。计算了比值比（ORs）和相应的 95% 置信区间（CIs），以检验统计能力。结果：本荟萃分析共纳入了 6 项研究，涉及 12982 名受试者，以评估 rs7903146 C/T 多态性与 DR 易感性之间的关联。合成结果表明，rs7903146 C/T 多态性突变可能伴随着 DR 风险的增加（T vs. C：OR = 1.26，95% CI = 1.00-1.60, p = 0.05, I2 = 83.5%；TT vs. CC: OR = 1.79, 95% CI = 1.12-2.86, p = 0.02, I2 = 80.2%；TT vs. CC + CT: OR = 1.62, 95% CI = 1.38-1.92, p < 0.01, I2 = 32.3%）。此外，亚组分析还显示，白种人后代中出现 T 突变的 DR 风险增加：目前的荟萃分析证据表明，TCF7L2 rs7903146 C/T 多态性可能在DR易感性中扮演重要角色。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic Research 医学-眼科学

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.

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