Role of gut-microbiota in disease severity and clinical outcomes.

IF 2.5 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Briefings in Functional Genomics Pub Date : 2024-01-18 DOI:10.1093/bfgp/elac037

Monika Yadav, Nar Singh Chauhan

引用次数: 0

Abstract

A delicate balance of nutrients, antigens, metabolites and xenobiotics in body fluids, primarily managed by diet and host metabolism, governs human health. Human gut microbiota is a gatekeeper to nutrient bioavailability, pathogens exposure and xenobiotic metabolism. Human gut microbiota starts establishing during birth and evolves into a resilient structure by adolescence. It supplements the host's metabolic machinery and assists in many physiological processes to ensure health. Biotic and abiotic stressors could induce dysbiosis in gut microbiota composition leading to disease manifestations. Despite tremendous scientific advancements, a clear understanding of the involvement of gut microbiota dysbiosis during disease onset and clinical outcomes is still awaited. This would be important for developing an effective and sustainable therapeutic intervention. This review synthesizes the present scientific knowledge to present a comprehensive picture of the role of gut microbiota in the onset and severity of a disease.

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肠道微生物群在疾病严重程度和临床结果中的作用。

体液中的营养素、抗原、代谢物和异种生物的微妙平衡，主要由饮食和宿主新陈代谢管理，决定着人类的健康。人体肠道微生物群是营养素生物利用率、病原体暴露和异生物代谢的守门员。人体肠道微生物群在出生时就开始建立，到青春期时逐渐形成一个有弹性的结构。它补充宿主的新陈代谢机制，协助许多生理过程，确保健康。生物和非生物压力因素会导致肠道微生物群组成失调，从而引发疾病。尽管科学取得了巨大进步，但人们仍有待清楚地了解肠道微生物群失调在疾病发生和临床结果中的参与情况。这对于制定有效、可持续的治疗干预措施非常重要。本综述综合了现有的科学知识，全面介绍了肠道微生物群在疾病发病和严重程度中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Briefings in Functional Genomics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-GENETICS & HEREDITY

CiteScore

6.30

自引率

2.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Briefings in Functional Genomics publishes high quality peer reviewed articles that focus on the use, development or exploitation of genomic approaches, and their application to all areas of biological research. As well as exploring thematic areas where these techniques and protocols are being used, articles review the impact that these approaches have had, or are likely to have, on their field. Subjects covered by the Journal include but are not restricted to: the identification and functional characterisation of coding and non-coding features in genomes, microarray technologies, gene expression profiling, next generation sequencing, pharmacogenomics, phenomics, SNP technologies, transgenic systems, mutation screens and genotyping. Articles range in scope and depth from the introductory level to specific details of protocols and analyses, encompassing bacterial, fungal, plant, animal and human data. The editorial board welcome the submission of review articles for publication. Essential criteria for the publication of papers is that they do not contain primary data, and that they are high quality, clearly written review articles which provide a balanced, highly informative and up to date perspective to researchers in the field of functional genomics.