Hyponatremia in Melioidosis: Analysis of 10-year Data from a Hospital-Based Registry.

IF 1 Q4 INFECTIOUS DISEASES
Journal of Global Infectious Diseases Pub Date : 2022-04-14 eCollection Date: 2022-04-01 DOI:10.4103/jgid.jgid_110_21
Indu Ramachandra Rao, Tushar Shaw, Ravindra Attur Prabhu, Vandana Kalwaje Eshwara, Shankar Prasad Nagaraju, Dharshan Rangaswamy, Srinivas Vinayak Shenoy, Mohan Varadanayakanahalli Bhojaraja, Chiranjay Mukhopadhyay
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引用次数: 0

Abstract

Introduction: Hyponatremia is a frequent finding in hospitalized patients and is associated with poor clinical outcomes. While hyponatremia is known to commonly occur in certain infections, its association with melioidosis has not been studied previously. We studied incidence and impact of hyponatremia on clinical outcomes in melioidosis.

Methods: This was a retrospective analysis of a single-center hospital registry of culture-positive patients with melioidosis hospitalized during a 10-year period (January 01, 2010, through January 31, 2021). Hyponatremia was defined as serum sodium of <135 mmol/L, and severe hyponatremia as serum sodium <120 mmol/L. The association of hyponatremia with in-hospital mortality, need for intensive care unit (ICU) stay and mechanical ventilation was studied.

Results: Of 201 patients with melioidosis, 169 (84.1%) had hyponatremia, with severe hyponatremia in 35 (17.4%) patients. Older age (adjusted odds ratios [OR] 1.03, 95% confidence intervals [CI]: 1.00-1.06; P = 0.049) and acute kidney injury (AKI) (adjusted OR 3.30, 95% CI: 1.19-9.19; P = 0.02) were independently associated with hyponatremia. Twenty-two patients had been evaluated for cause of hyponatremia and of these, 11 (50%) had syndrome of inappropriate antidiuresis. Severe hyponatremia was associated with in-hospital mortality (adjusted OR 3.75, 95% CI: 1.37-10.27; P = 0.01), need for ICU stay (adjusted OR 7.04, 95% CI: 2.88-17.19; P < 0.001) and mechanical ventilation (adjusted OR 3.99, 95% CI: 1.54-10.32; P = 0.004).

Conclusion: Hyponatremia occurs in 84.1% of hospitalized patients with melioidosis. Older age and AKI are associated with a higher incidence of hyponatremia. The presence of severe hyponatremia is an independent predictor of in-hospital mortality, need for mechanical ventilation and ICU stay.

类鼻疽患者的低钠血症:基于医院登记的10年数据分析
导读:低钠血症是住院患者的常见病,与不良临床预后相关。虽然已知低钠血症通常发生在某些感染中,但其与类鼻疽病的关系尚未得到研究。我们研究了类鼻疽患者低钠血症的发生率及其对临床预后的影响。方法:回顾性分析10年期间(2010年1月1日至2021年1月31日)住院的类鼻疽病培养阳性患者的单中心医院登记。结果:201例类鼻疽患者中,169例(84.1%)存在低钠血症,其中重度低钠血症35例(17.4%)。老年人(校正优势比[OR] 1.03, 95%可信区间[CI]: 1.00-1.06;P = 0.049)和急性肾损伤(AKI)(校正OR 3.30, 95% CI: 1.19-9.19;P = 0.02)与低钠血症独立相关。22例患者被评估为低钠血症的原因,其中11例(50%)有不适当的抗利尿综合征。严重低钠血症与住院死亡率相关(调整OR 3.75, 95% CI: 1.37-10.27;P = 0.01)、ICU住院需求(调整OR 7.04, 95% CI: 2.88 ~ 17.19;P < 0.001)和机械通气(调整后OR 3.99, 95% CI: 1.54-10.32;P = 0.004)。结论:84.1%的类鼻疽住院患者存在低钠血症。老年和AKI与低钠血症的高发生率相关。严重低钠血症的存在是院内死亡率、机械通气需求和ICU住院时间的独立预测因子。
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来源期刊
CiteScore
3.30
自引率
0.00%
发文量
31
审稿时长
29 weeks
期刊介绍: JGID encourages research, education and dissemination of knowledge in the field of Infectious Diseases across the world thus promoting translational research by striking a synergy between basic science, clinical medicine and public health. The Journal intends to bring together scientists and academicians in Infectious Diseases to promote translational synergy between Laboratory Science, Clinical Medicine and Public Health. The Journal invites Original Articles, Clinical Investigations, Epidemiological Analysis, Data Protocols, Case Reports, Clinical Photographs, review articles and special commentaries. Students, Residents, Academicians, Public Health experts and scientists are all encouraged to be a part of this initiative by contributing, reviewing and promoting scientific works and science.
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