As a Modulator, Multitasking Roles of SIRT1 in Respiratory Diseases.

IF 4.3 4区 医学 Q2 IMMUNOLOGY
Immune Network Pub Date : 2022-06-20 eCollection Date: 2022-06-01 DOI:10.4110/in.2022.22.e21
Yunxin Zhou, Fan Zhang, Junying Ding
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引用次数: 4

Abstract

As far the current severe coronavirus disease 2019 (COVID-19), respiratory disease is still the biggest threat to human health. In addition, infectious respiratory diseases are particularly prominent. In addition to killing and clearing the infection pathogen directly, regulating the immune responses against the pathogens is also an important therapeutic modality. Sirtuins belong to NAD+-dependent class III histone deacetylases. Among 7 types of sirtuins, silent information regulator type-1 (SIRT1) played a multitasking role in modulating a wide range of physiological processes, including oxidative stress, inflammation, cell apoptosis, autophagy, antibacterial and antiviral functions. It showed a critical effect in regulating immune responses by deacetylation modification, especially through high-mobility group box 1 (HMGB1), a core molecule regulating the immune system. SIRT1 was associated with many respiratory diseases, including COVID-19 infection, bacterial pneumonia, tuberculosis, and so on. Here, we reviewed the latest research progress regarding the effects of SIRT1 on immune system in respiratory diseases. First, the structure and catalytic characteristics of SIRT1 were introduced. Next, the roles of SIRT1, and the mechanisms underlying the immune regulatory effect through HMGB1, as well as the specific activators/inhibitors of SIRT1, were elaborated. Finally, the multitasking roles of SIRT1 in several respiratory diseases were discussed separately. Taken together, this review implied that SIRT1 could serve as a promising specific therapeutic target for the treatment of respiratory diseases.

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SIRT1在呼吸系统疾病中的多任务调节作用
就目前的严重冠状病毒病2019 (COVID-19)而言,呼吸道疾病仍然是对人类健康的最大威胁。此外,传染性呼吸道疾病尤为突出。除了直接杀灭和清除感染病原体外,调节对病原体的免疫反应也是一种重要的治疗方式。Sirtuins属于依赖NAD+的III类组蛋白去乙酰化酶。在7种sirtuins中,沉默信息调节因子1型(silent information regulator type-1, SIRT1)在多种生理过程中发挥多任务作用,包括氧化应激、炎症、细胞凋亡、自噬、抗菌和抗病毒功能。它通过去乙酰化修饰,特别是通过调节免疫系统的核心分子高迁移率组框1 (HMGB1),在调节免疫应答中发挥了关键作用。SIRT1与许多呼吸道疾病有关,包括COVID-19感染、细菌性肺炎、结核病等。本文就SIRT1在呼吸系统疾病中对免疫系统影响的最新研究进展进行综述。首先介绍了SIRT1的结构和催化特性。接下来,阐述了SIRT1的作用,以及通过HMGB1产生免疫调节作用的机制,以及SIRT1的特异性激活/抑制因子。最后,分别讨论了SIRT1在几种呼吸系统疾病中的多任务作用。综上所述,这篇综述表明SIRT1可以作为治疗呼吸系统疾病的一个有希望的特异性治疗靶点。
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来源期刊
Immune Network
Immune Network Immunology and Microbiology-Immunology
CiteScore
2.90
自引率
3.30%
发文量
36
期刊介绍: Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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