Two birds, one stone: host-guest complex of indocyanine green–β-cyclodextrin for fundus angiography

IF 2.3 4区化学 Q2 Agricultural and Biological Sciences

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-07-31 DOI:10.1007/s10847-022-01154-1

Qin Tang, Fei Xu, Chuanli Zhang, Chang Li, Feng Liu, Ming Shen, Xun Liu, Jiaqi Lin, Limin Zhu, Tingting Lin, Di Sun

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Abstract

Indocyanine green (ICG) angiography is of great importance for ophthalmic diagnostic applications and is mainly used to check for choroidal vascular diseases. However, ICG fluorescence imaging probes aggregate in water because they have sulfonyl groups and can form dimers and oligomers. This effect thus reduces the fluorescence of the probes. Therefore, we have established a simple and effective way to prepare β-cyclodextrinmodified ICG (ICG–β-CD) via the host–guest assembly process. In contrast to ICG, ICG–β-CD avoided solution aggregation. Moreover, it exhibited improved absorption intensity. When used as an angiographic contrast agent for ophthalmic choroid examination and diagnosis in SD rats, the fluorescence imaging effect of ICG–β-CD on retinal and choroidal vessels was better than that of ICG on choroidal vessels. Therefore, ICG–β-CD is expected to achieve a "two birds with one stone" effect.

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两鸟一石:吲哚菁绿- β-环糊精主客体复合物眼底血管造影

吲哚菁绿(ICG)血管造影在眼科诊断中具有重要的应用价值，主要用于检查脉络膜血管疾病。然而，ICG荧光成像探针在水中聚集，因为它们具有磺酰基，可以形成二聚体和低聚物。这种效应因此降低了探针的荧光。因此，我们建立了一种简单有效的主客体组装法制备β-环糊精修饰ICG (ICG -β-CD)的方法。与ICG相比，ICG -β-CD避免了溶液聚集。此外，它的吸收强度也有所提高。作为血管造影造影剂用于SD大鼠眼部脉络膜检查诊断时，ICG -β-CD对视网膜和脉络膜血管的荧光成像效果优于ICG对脉络膜血管的荧光成像效果。因此，ICG -β-CD有望达到“一石二鸟”的效果。

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来源期刊

Journal of Inclusion Phenomena and Macrocyclic Chemistry 化学-化学综合

CiteScore

3.30

自引率

8.70%

发文量

审稿时长

3-8 weeks

期刊介绍： The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.