Intestinal fatty acid binding protein: A rising therapeutic target in lipid metabolism

IF 14 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in lipid research Pub Date : 2022-07-01 DOI:10.1016/j.plipres.2022.101178

Xi Huang, Youci Zhou, Yunwei Sun, Qijun Wang

{"title":"Intestinal fatty acid binding protein: A rising therapeutic target in lipid metabolism","authors":"Xi Huang, Youci Zhou, Yunwei Sun, Qijun Wang","doi":"10.1016/j.plipres.2022.101178","DOIUrl":null,"url":null,"abstract":"<div>Fatty acid binding proteins (FABPs) are key proteins in lipid transport, and the isoforms are segregated according to their tissue origins. Several isoforms, such as adipose-FABP and epidermal-FABP, have been shown to participate in multiple pathologic processes due to their ubiquitous expression. Intestinal fatty acid binding protein, also termed FABP2 or I-FABP, is specifically expressed in the small intestine. FABP2 can traffic lipids from the intestinal lumen to enterocytes and bind superfluous fatty acids to maintain a steady pool of fatty acids in the epithelium. As a lipid chaperone, FABP2 can also carry lipophilic drugs to facilitate targeted transport. When the integrity of the intestinal epithelium is disrupted, FABP2 is released into the circulation. Thus, it can potentially serve as a clinical biomarker. In this review, we discuss the pivotal role of FABP2 in intestinal lipid metabolism. We also summarize the molecular interactions that have been reported to date, highlighting the clinical prospects of FABP2 research.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"87 ","pages":"Article 101178"},"PeriodicalIF":14.0000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in lipid research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0163782722000339","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 13

Abstract

Fatty acid binding proteins (FABPs) are key proteins in lipid transport, and the isoforms are segregated according to their tissue origins. Several isoforms, such as adipose-FABP and epidermal-FABP, have been shown to participate in multiple pathologic processes due to their ubiquitous expression. Intestinal fatty acid binding protein, also termed FABP2 or I-FABP, is specifically expressed in the small intestine. FABP2 can traffic lipids from the intestinal lumen to enterocytes and bind superfluous fatty acids to maintain a steady pool of fatty acids in the epithelium. As a lipid chaperone, FABP2 can also carry lipophilic drugs to facilitate targeted transport. When the integrity of the intestinal epithelium is disrupted, FABP2 is released into the circulation. Thus, it can potentially serve as a clinical biomarker. In this review, we discuss the pivotal role of FABP2 in intestinal lipid metabolism. We also summarize the molecular interactions that have been reported to date, highlighting the clinical prospects of FABP2 research.

查看原文本刊更多论文

肠道脂肪酸结合蛋白:脂质代谢的新治疗靶点

脂肪酸结合蛋白(Fatty acid binding protein, FABPs)是脂质转运的关键蛋白，其异构体根据其组织来源而分离。脂肪- fabp和表皮- fabp等几种同工型，由于其普遍表达，已被证明参与多种病理过程。肠脂肪酸结合蛋白，也称为FABP2或I-FABP，在小肠中特异性表达。FABP2可以将脂质从肠腔输送到肠细胞，并结合多余的脂肪酸以维持上皮内稳定的脂肪酸池。作为脂质伴侣，FABP2还可以携带亲脂性药物，促进靶向转运。当肠上皮的完整性被破坏时，FABP2被释放到循环中。因此，它可以作为一种潜在的临床生物标志物。在这篇综述中，我们讨论了FABP2在肠道脂质代谢中的关键作用。我们还总结了迄今为止报道的分子相互作用，强调了FABP2研究的临床前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Progress in lipid research 生物-生化与分子生物学

CiteScore

24.50

自引率

2.20%

发文量

审稿时长

14.6 weeks

期刊介绍： The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.