Investigation of how stimulation intensity of rTMS affects magneto permeabilization of the Blood-Brain Barrier (BBB).

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-07-03 Epub Date: 2022-07-06 DOI:10.1080/15368378.2022.2095644

Behrouz Vejdani Afkham, Zeinab Shankayi, Farideh Bahrami, Seyed Mohammad Firoozabadi, Sahel Heydarheydari, Mohammad Taghi Mohammadi

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引用次数: 1

Abstract

The present study aimed to assess the effect of the rTMS (repetitive Transcranial Magnetic Stimulation) intensity on the permeability of the BBB for brain-targeted drug delivery. For this purpose, different rTMS intensities including 70%, 100%, and 130% of Resting Motor Threshold (RMT) assessed in three groups of rats (three groups of 5 rats). Stimulation applied over the right hemisphere of the animals. The first phase of the study was composed of intravenous administration of Evans Blue Dye (EBD), rTMS stimulation and EBD uptake measurement in both brain hemispheres. The second examination was included rTMS stimulation, injection of the MRI Contrast Agent (CA), and signal intensity measurement in post-contrast images. Each exam also included five rats in a sham group. Thus, the total of 40 male Wistar rats enrolled in this study. There was no significant difference in the amount of EBD accumulated between the right hemisphere of the brain in the sham group and the group with 70% RMT magnetic stimulation, while this figure was significantly higher than the sham group for both 100 and 130% RMT groups. There was also a significant difference in this index between 100 and 130% groups. All of the results from the first phase of the study were consistent with the second assessment representing an upward trend of induced permeability by rising rTMS intensity. The results of this study imply that to cause an effective temporary disruption in the BBB the intensity of 100% RMT or above should be used for stimulation.

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rTMS刺激强度对血脑屏障磁通透性影响的研究。

本研究旨在评估rTMS(重复经颅磁刺激)强度对脑屏障通透性的影响。为此，在三组大鼠(三组5只大鼠)中评估不同的rTMS强度，包括70%、100%和130%的静息运动阈值(RMT)。在动物的右半球上施加刺激。研究的第一阶段包括静脉注射埃文斯蓝染料(EBD)， rTMS刺激和双脑半球EBD摄取测量。第二次检查包括rTMS刺激，注射MRI造影剂(CA)，并在对比后图像中测量信号强度。每次检查还包括5只大鼠作为假组。因此，共有40只雄性Wistar大鼠被纳入本研究。假手术组与70% RMT磁刺激组右脑EBD积累量无显著差异，而100和130% RMT组的EBD积累量均显著高于假手术组。该指数在100和130%组之间也有显著差异。第一阶段研究的所有结果都与第二阶段的评估结果一致，即rTMS强度的增加使诱导渗透率呈上升趋势。本研究的结果表明，为了引起血脑屏障的有效暂时破坏，应该使用100% RMT或更高强度的刺激。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.