Adhesion molecules: a way to understand lupus.

IF 1.4 Q3 RHEUMATOLOGY
Reumatologia Pub Date : 2022-01-01 Epub Date: 2022-05-18 DOI:10.5114/reum.2022.115664
Karolina Nowak, Olga Gumkowska-Sroka, Przemysław Kotyla
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引用次数: 5

Abstract

Systemic lupus erythematosus is a connective disease in which all vitally important organs may be affected. The etiology of the disease is largely unknown and almost all immunological mechanisms have been proposed as the pathophysiological background of the disease. Among them, endothelial damage and dysfunction seem to play a pivotal role. Endothelial damage can be accurately measured using adhesion molecules such asintercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), platelet endothelial cell adhesion molecule (PECAM) and selectins. In this review we discuss the role of well-known cellular adhesion molecules as pathogenic factors in disease development as well as disease activity biomarkers.

Abstract Image

粘附分子:了解狼疮的一种方法。
系统性红斑狼疮是一种结缔组织疾病,所有重要器官都可能受到影响。该病的病因在很大程度上是未知的,几乎所有的免疫机制已被提出作为疾病的病理生理背景。其中,内皮损伤和功能障碍似乎起着关键作用。内皮损伤可以使用粘附分子如细胞间粘附分子(ICAM)、血管细胞粘附分子(VCAM)、血小板内皮细胞粘附分子(PECAM)和选择素等精确测量。在这篇综述中,我们讨论了众所周知的细胞粘附分子在疾病发展中的致病因素以及疾病活性生物标志物的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reumatologia
Reumatologia Medicine-Rheumatology
CiteScore
2.70
自引率
0.00%
发文量
44
审稿时长
10 weeks
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