lncRNA ACTA2-AS1 predicts malignancy and poor prognosis of triple-negative breast cancer and regulates tumor progression via modulating miR-532-5p.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2022-07-27 DOI:10.1186/s12860-022-00432-7

Yi Peng, Xiaoxi Huang, Hongmei Wang

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Abstract

Background: Dysregulation of ACTA2-AS1 and miR-532-5p and their functions in various cancers have been widely reported. Their potential of serving as biomarkers in triple-negative breast cancer (TNBC) remains unknown. This study aimed to evaluate the function of ACTA2-AS1 and miR-532-5p and their potential of serving as biomarkers in TNBC.

Results: The TNBC tissues were collected from 119 patients, where the reduced level of ACTA2-AS1 and increased level of miR-532-5p were observed by PCR and showed a significantly negative correlation (P < 0.001). Both ACTA2-AS1 and miR-532-5p were closely associated with the malignant development and poor prognosis of TNBC patients. Moreover, in TNBC cell, overexpressing ACTA2-AS1 was found to suppress cell proliferation and metastasis, which was reversed by the upregulation of miR-532-5p.

Conclusions: ACTA2-AS1 and miR-532-5p could act as biomarkers of TNBC predicting the progression and prognosis of patients. ACTA2-AS1 served as a tumor suppressor of TNBC which was mediated by miR-532-5p.

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lncRNA ACTA2-AS1可预测三阴性乳腺癌的恶性和不良预后，并通过调节miR-532-5p调控肿瘤进展。

背景:ACTA2-AS1和miR-532-5p的失调及其在各种癌症中的功能已经被广泛报道。它们作为三阴性乳腺癌(TNBC)生物标志物的潜力尚不清楚。本研究旨在评估ACTA2-AS1和miR-532-5p的功能及其作为TNBC生物标志物的潜力。结果:收集119例TNBC患者的TNBC组织，通过PCR观察到ACTA2-AS1水平降低，miR-532-5p水平升高，并呈显著负相关(P)结论:ACTA2-AS1和miR-532-5p可作为TNBC的生物标志物，预测患者的进展和预后。ACTA2-AS1作为TNBC的抑瘤因子，miR-532-5p介导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464