Inhaled Loxapine as a Rapid Treatment for Agitation in Patients with Personality Disorder: A Prospective Study on the Effects of Time.

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-08-31 DOI:10.9758/cpn.2022.20.3.482

Marc Ferrer, Óscar Soto-Angona, María Soler-Artigas, Pol Ibáñez, Christian Fadeuilhe, Raúl Felipe Palma-Álvarez, Raquefet Lidai, Sebastian Vargas-Cáceres, María Ángeles Torrecilla, Anna López, Josep Antoni Ramos-Quiroga

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引用次数: 1

Abstract

Objective: Agitation in patients diagnosed with personality disorders (PD) is one of the most frequent crises in emergency departments (ED). Although many medications have been tested, their effectiveness has been small or non-significant, and no specific drugs are supported by the available evidence. This study aimed to evaluate the efficacy of Inhaled loxapine (IL) as a therapeutic option for agitated patients with PD.

Methods: A naturalistic, unicentric, prospective study was carried out. Thirty subjects diagnosed with PD and attending the ED with episodes of agitation were recruited most of whom were women diagnosed with Borderline Personality Disorder. Subjects were treated with a single dose of IL (9.1 mg). Efficacy was assessed with the Clinical Global Impression scale, the Excited Component of the Positive and Negative Syndrome Scale (PANSS-EC) and the Agitation-Calmness Evaluation Scale (ACES). Patients were followed 60 minutes after administration to measure IL effect and its duration.

Results: IL exhibited an overall efficacy in managing mild to severe agitation, with a quick onset of effect and persistence. 'Effect of time', where IL efficacy is maintained over time, is more marked in higher-severity agitation. No additional treatments were needed to improve agitation during the follow-up time.

Conclusion: Results suggest that IL could be a safe and effective option to manage agitation in PD.

Abstract Image

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吸入洛沙平快速治疗人格障碍患者躁动:时间效应的前瞻性研究

目的:人格障碍(PD)患者的躁动是急诊科(ED)最常见的危机之一。虽然许多药物已经经过测试，但它们的有效性很小或不显著，而且没有任何特定的药物得到现有证据的支持。本研究旨在评估吸入洛沙平(IL)作为躁动PD患者的治疗选择的疗效。方法:采用自然、单中心、前瞻性研究。30名被诊断为PD并伴有躁动发作的受试者被招募到急诊科，其中大多数是被诊断为边缘型人格障碍的女性。受试者接受单剂量IL (9.1 mg)治疗。采用临床总体印象量表、阳性和阴性症状兴奋成分量表(PANSS-EC)和激动-平静评估量表(ACES)评估疗效。患者在给药后60分钟随访，测量IL的效果及其持续时间。结果:IL在管理轻度至重度躁动方面表现出总体疗效，具有快速起效和持久性。“时间效应”，IL的功效随着时间的推移而保持，在更严重的躁动中更为明显。在随访期间，不需要额外的治疗来改善躁动。结论:结果提示IL是一种安全有效的治疗PD患者躁动的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.