{"title":"Anticancer effects of metformin in experimental animal models of different types of cancer: a systematic review and meta-analysis.","authors":"Fan Zhang, Shuai Han, Weijie Song","doi":"10.1186/s42826-022-00131-6","DOIUrl":null,"url":null,"abstract":"<p><p>To systematically evaluate the effects of metformin on tumors in experimental animal models of different types of cancer. Pubmed, Embase, Cochrane, and Web of Science databases were searched for studies on metformin used in various experimental animal tumor models from 2008 to 2022. Meta-analysis was performed using STATA 16.0 software after screening literature extraction data and methodological quality evaluation by inclusion and exclusion criteria. A total of 24 studies with 1108 model animals were included. Meta-analysis results showed that this study used meta-analysis for quantitative synthesis of study results and found that tumor model animals of different species showed different degrees of reduction in tumor volume, weight, and number after metformin intervention.</p>","PeriodicalId":17993,"journal":{"name":"Laboratory Animal Research","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297580/pdf/","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Laboratory Animal Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s42826-022-00131-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 3
Abstract
To systematically evaluate the effects of metformin on tumors in experimental animal models of different types of cancer. Pubmed, Embase, Cochrane, and Web of Science databases were searched for studies on metformin used in various experimental animal tumor models from 2008 to 2022. Meta-analysis was performed using STATA 16.0 software after screening literature extraction data and methodological quality evaluation by inclusion and exclusion criteria. A total of 24 studies with 1108 model animals were included. Meta-analysis results showed that this study used meta-analysis for quantitative synthesis of study results and found that tumor model animals of different species showed different degrees of reduction in tumor volume, weight, and number after metformin intervention.
系统评价二甲双胍对不同类型肿瘤实验动物模型的肿瘤作用。检索Pubmed、Embase、Cochrane和Web of Science数据库，检索2008年至2022年在各种实验动物肿瘤模型中使用二甲双胍的研究。对文献提取资料进行筛选，采用纳入标准和排除标准进行方法学质量评价后，采用STATA 16.0软件进行meta分析。共纳入24项研究，模型动物1108只。meta分析结果显示，本研究采用meta分析对研究结果进行定量综合，发现不同物种的肿瘤模型动物在二甲双胍干预后，肿瘤体积、重量、数量均有不同程度的减少。
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