Signs and symptoms method in neuropsychology: A standardized observational examination of cognitive functions can be effective in detecting mild cognitive impairment.

IF 2.6 3区心理学 Q3 NEUROSCIENCES

Neuropsychology Pub Date : 2023-10-01 Epub Date: 2022-11-28 DOI:10.1037/neu0000871

Pietro Davide Trimarchi, Emma Sanfilippo, Alessia Gallucci, Silvia Inglese, Emanuele Tomasini, Anna Fontanella, Isabella Rebecchi, Stefania Fracchia, Paola Maria Rita Parisi, Federica Tartarone, Fabrizio Giunco, Carlo Abbate

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引用次数: 0

Abstract

Objective: The present study aimed at investigating the sensitivity and specificity of the NeuroPsychological Examination (NPE), a systematic collection of cognitive signs and symptoms based on the observation of the patient's behavior during a clinical interview, in detecting Mild Cognitive Impairment (MCI).

Method: 475 participants, 208 suffering from MCI, 188 suffering from dementia and 79 subjective cognitive decline (SCD), have been assessed using NPE for the presence of signs and symptoms of cognitive impairment. Receiver operating characteristic (ROC) curve analysis and the Youden's test were used to determine the more appropriate cutoff points for the number of neuropsychological signs at the NPE that enabled to discriminate SCD from MCI, SCD from dementia and MCI from dementia. A sensitivity and specificity analysis and comparisons among the three groups were conducted.

Results: The mean number of signs at the NPE were 1.73 for SCD, 7.98 for MCI and 12.82 for dementia. Pairwise comparisons among the three group of participants showed significant differences (SCD vs. MCI, p < .001, r = -0.66; SCD vs. dementia, p < .001, r = -0.76; MCI vs. dementia, p < .001, r = -0.44). The criterion of 3 signs at the NPE showed a sensitivity of 0.95 (95% CI [0.91, 0.97]) and a specificity of 0.76 (95% CI [0.65, 0.84]) in discriminating SCD from MCI participants.

Conclusions: A signs and symptoms approach could be a useful tool for clinical neuropsychologists working in the field of MCI and dementia assessment. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

查看原文本刊更多论文

神经心理学中的体征和症状方法：认知功能的标准化观察性检查可以有效地检测轻度认知障碍。

目的：本研究旨在探讨神经心理检查（NPE）在检测轻度认知障碍（MCI）方面的敏感性和特异性。NPE是一种基于临床访谈中患者行为观察的认知体征和症状的系统集合。方法：475名参与者，208名MCI患者，188名患有痴呆症的患者和79名主观认知能力下降（SCD）的患者已经使用NPE评估了认知障碍迹象和症状的存在。受试者操作特征（ROC）曲线分析和Youden检验用于确定NPE神经心理体征数量的更合适的临界点，该临界点能够区分SCD与MCI、SCD与痴呆以及MCI与痴呆。对三组患者进行了敏感性和特异性分析和比较。结果：SCD、MCI和痴呆的NPE平均体征数分别为1.73、7.98和12.82。三组参与者之间的配对比较显示出显著差异（SCD与MCI，p<.001，r=-0.66；SCD与痴呆，p<.001，r=-0.76；MCI与痴呆，p<.001，r=-0.44）。NPE的3个体征标准显示，区分SCD和MCI参与者的敏感性为0.95（95%CI[0.91，0.97]），特异性为0.76（95%CI[0.65，0.84]）。结论：体征和症状方法可能是从事MCI和痴呆评估领域的临床神经心理学家的有用工具。（PsycInfo数据库记录（c）2023 APA，保留所有权利）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychology 医学-神经科学

CiteScore

4.10

自引率

4.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.