Effects of imbalance of lipid metabolism through NF-KB pathway on atherosclerosis and vascular aging in rats.

Cellular and molecular biology (Noisy-le-Grand, France) Pub Date : 2022-02-04 DOI:10.14715/cmb/2021.67.5.20

Xiangyong Kong, Hongwu Chen, Dan Li, Likun Ma

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引用次数: 5

Abstract

Cardiovascular diseases have become a mainstream disease by intensifying the country's population aging. The purpose of this article is to explore the specific effect and mechanism of lipid metabolism imbalance through the NF-KB pathway on atherosclerosis and vascular aging in rats. Twenty healthy adult rats were randomly divided into two groups, control in the observation group and the observation group. The rats in the observation group were fed a high-fat diet to imbalance the lipid metabolism of the rats. Immunohistochemistry and transmission electron microscope detectors were used to observe the NF-KB pathway in rats and study atherosclerosis-specific conditions of sclerosis and vascular aging. The results show that the imbalance of lipid metabolism through the NF-KB pathway can increase the rate of apoptosis in rat blood vessels by 24% and the proliferation rate by 18%. The number of vascular endothelial cell damage increased by 33%, which promoted atherosclerosis in rats and increased the rate of vascular aging in rats by 27%.

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NF-KB途径脂质代谢失衡对大鼠动脉粥样硬化和血管衰老的影响。

随着我国人口老龄化的加剧，心血管疾病已成为一种主流疾病。本文旨在通过NF-KB途径探讨脂质代谢失衡对大鼠动脉粥样硬化和血管衰老的具体作用及机制。选取健康成年大鼠20只，随机分为观察组和对照组。观察组饲喂高脂饲料，使大鼠脂质代谢失衡。采用免疫组织化学和透射电镜检测器观察大鼠NF-KB通路，研究动脉粥样硬化特异性硬化条件和血管老化。结果表明，NF-KB通路脂质代谢失衡可使大鼠血管细胞凋亡率提高24%，增殖率提高18%。血管内皮细胞损伤数量增加33%，促进大鼠动脉粥样硬化，使大鼠血管老化率增加27%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cellular and molecular biology (Noisy-le-Grand, France)

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