Breastfeeding and Breast Cancer Risk: Our Experience and Mini-review of the Literature.

Anastasia Bothou, Stefanos Zervoudis, Maria Iliadou, Panagiota Pappou, Georgios Iatrakis, Georgios Tsatsaris, Panagiotis Peitsidis, Aggeliki Gerende, Anna Chalkidou, Xanthi Anthoulaki, Nikolaos Nikolettos, Panagiotis Tsikouras
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Abstract

Background: According to data from World Health Organization, breast cancer constitutes the second most common diagnosed malignancy after lung cancer and the second leading cause of death among women in 2020, worldwide. The protective role of breastfeeding in the emergence of breast malignancy has been mentioned in several studies, indicating the important part it can have in the effort of reducing breast cancer's incidence.

Objective: To investigate a possible association between breastfeeding and breast cancer risk in Greek women.

Methods: Totally, 391 women participated in our case-control retrospective study. In the case group included 238 women with breast cancer, while in control group 153 women without breast cancer who were enrolled in two breast clinics in Greece. All women were examined clinically and with breast ultrasound, while those older than 40 years old also with bilateral digital mammography.

Results: The x2 (chi-square) test found a statistically significant reverse correlation between breast cancer and breastfeeding ⩾12 months (cumulative) (p = 0.001). It was observed that the percentages of patients who breastfed ⩾12 months were lower than those of healthy women.

Conclusion: Breastfeeding and particularly the cumulative period of ⩾12 months is related to the maximum of the protection from breast cancer.

母乳喂养和乳腺癌风险:我们的经验和文献综述。
背景:根据世界卫生组织的数据,到2020年,乳腺癌是仅次于肺癌的第二大最常见的恶性肿瘤,也是全球妇女死亡的第二大原因。几项研究都提到了母乳喂养对乳腺恶性肿瘤发生的保护作用,这表明母乳喂养在降低乳腺癌发病率方面可以发挥重要作用。目的:调查希腊妇女母乳喂养与乳腺癌风险之间的可能联系。方法:共有391名女性参与了我们的病例对照回顾性研究。病例组包括238名患有乳腺癌的妇女,而对照组包括153名未患乳腺癌的妇女,她们在希腊的两家乳腺诊所登记。所有女性都接受了临床检查和乳房超声检查,而40岁以上的女性也接受了双侧数字乳房x光检查。结果:x2(卡方)检验发现乳腺癌与母乳喂养大于或等于12个月(累积)之间具有统计学意义的反向相关性(p = 0.001)。观察到,母乳喂养大于或等于12个月的患者的百分比低于健康女性。结论:母乳喂养,特别是大于或等于12个月的累积期与最大限度地保护乳腺癌有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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