Epidemiology of biopsy-proven glomerular diseases in Chinese children: A scoping review

Q1 Medicine

Chronic Diseases and Translational Medicine Pub Date : 2022-09-28 DOI:10.1002/cdt3.46

Yetong Li, Yue Yang, Li Zhuo, Dan Wu, Wenge Li, Xiaorong Liu

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引用次数: 3

Abstract

Background

Glomerular disease is the leading cause of chronic kidney disease globally. No scoping review reports have focused on China's spectrum of glomerular diseases in children. This study aimed to systematically identify and describe retrospective studies on pediatric glomerular disease based on available data on sex, age, study period, and region.

Methods

Six databases were systematically searched for relevant studies from initiation to December 2021 in PubMed, Embase, Web of Science, Global Health Library, Wangfang Database, and CNKI.

Results

Thirty-four studies were identified in the scoping review, including 40,430 patients with biopsy-proven diagnoses. The proportion of boys was significantly higher than that of girls. In this study, 28,280 (70%) cases were primary glomerular disease, 10,547 (26.1%) cases were diagnosed as secondary glomerular disease, and 1146 (2.8%) cases were hereditary glomerular disease. Minimal change disease is the most common glomerular disease among children in China, followed by mesangial proliferative glomerulonephritis, IgA nephropathy, and purpura nephritis. We observed increments in glomerular diseases in periods 2 (2001–2010) and 3 (2011–2021). The proportion of major glomerular diseases varies significantly in the different regions of China.

Conclusion

The spectrum of pediatric glomerular diseases varied across sex, age groups, study periods, and regions, and has changed considerably over the past 30 years.

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中国儿童经活检证实的肾小球疾病的流行病学:范围综述

肾小球疾病是全球慢性肾脏疾病的主要原因。没有针对中国儿童肾小球疾病谱的范围审查报告。本研究旨在系统地识别和描述基于性别、年龄、研究期间和地区的现有数据的儿童肾小球疾病的回顾性研究。方法系统检索PubMed、Embase、Web of Science、全球健康图书馆、王方数据库、中国知网等6个数据库自启动至2021年12月的相关研究。结果:34项研究在范围回顾中被确定，包括40,430例活检证实诊断的患者。男生所占比例明显高于女生。原发性肾小球疾病28,280例(70%)，继发性肾小球疾病10,547例(26.1%)，遗传性肾小球疾病1146例(2.8%)。微小改变病是中国儿童最常见的肾小球疾病，其次是系膜增生性肾小球肾炎、IgA肾病和紫癜性肾炎。我们观察到第2期(2001-2010年)和第3期(2011-2021年)肾小球疾病增加。主要肾小球疾病的比例在中国不同地区差异显著。结论小儿肾小球疾病的谱在性别、年龄组、研究时期和地区之间存在差异，并且在过去30年中发生了很大变化。

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来源期刊

Chronic Diseases and Translational Medicine Medicine-General Medicine

CiteScore

6.70

自引率

0.00%

发文量

195

审稿时长

35 weeks

期刊介绍： This journal aims to promote progress from basic research to clinical practice and to provide a forum for communication among basic, translational, and clinical research practitioners and physicians from all relevant disciplines. Chronic diseases such as cardiovascular diseases, cancer, diabetes, stroke, chronic respiratory diseases (such as asthma and COPD), chronic kidney diseases, and related translational research. Topics of interest for Chronic Diseases and Translational Medicine include Research and commentary on models of chronic diseases with significant implications for disease diagnosis and treatment Investigative studies of human biology with an emphasis on disease Perspectives and reviews on research topics that discuss the implications of findings from the viewpoints of basic science and clinical practic.