Proanthocyanidins in grape seeds and their role in gut microbiota-white adipose tissue axis.

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2023-03-15 Epub Date: 2022-09-26 DOI:10.1016/j.foodchem.2022.134405

Yasmin Alaby Martins Ferreira, Giovana Jamar, Débora Estadella, Luciana Pellegrini Pisani

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引用次数: 7

Abstract

Several factors can impact the gut microbiota, affecting host metabolism and immunity. It implies intestinal barrier disruption and translocation of gut microbiota metabolites to the bloodstream, such as lipopolysaccharides (LPS). LPS is an endotoxin from gram-negative gut bacteria that trigger the activation of the Toll-like receptor-4 (TLR-4) inflammatory pathway and can modulate white adipose tissue (WAT) metabolism. Dietary components, including diets rich in fiber and polyphenols, contribute to intestinal environment homeostasis. Grape seed proanthocyanidins extract (GSPE) may improve intestinal permeability and microbial diversity and increase short-chain fatty acids production. Furthermore, GSPE has been involved in LPS reduction, down-regulating the TLR-4 pathway, decreasing the WAT metainflammatory profile, and preventing adipocyte hypertrophy. Studies have pointed out strategies to promote health and control obesity by modulating the gut microbiota environment. Therefore, this review aims to summarize the potential effects of GSPE on the gut microbiota-white adipose tissue axis against obesity.

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葡萄籽中的原花青素及其在肠道微生物群-白色脂肪组织轴中的作用。

有几个因素可以影响肠道微生物群，影响宿主的代谢和免疫。这意味着肠道屏障被破坏，肠道微生物代谢物(如脂多糖)转运到血液中。脂多糖是一种来自革兰氏阴性肠道细菌的内毒素，可触发toll样受体-4 (TLR-4)炎症通路的激活，并可调节白色脂肪组织(WAT)代谢。膳食成分，包括富含纤维和多酚的膳食，有助于肠道环境的稳态。葡萄籽原花青素提取物(GSPE)可以改善肠道通透性和微生物多样性，增加短链脂肪酸的产生。此外，GSPE还参与了LPS的减少，下调TLR-4通路，降低WAT的炎症谱，防止脂肪细胞肥大。研究指出了通过调节肠道菌群环境来促进健康和控制肥胖的策略。因此，本文旨在总结GSPE对肠道微生物群-白色脂肪组织轴抗肥胖的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

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