Acromegaly: an endocrine pathology with serious consequences

IF 0.4 4区 医学 Q4 MEDICAL LABORATORY TECHNOLOGY
Afef Horchani, Ines Bayar, Bilel Ben Amor, Ilhem Hellara, Mabrouk Abdelali, Fadoua Neffati, Ines Khochtali, Mohamed Fadhel Najjar
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引用次数: 0

Abstract

Acromegaly is a rare endocrine disorder leading to an acquired physical disfigurement and multisystem damage. It is caused in over 95% of cases by a secreting pituitary adenoma. Latency period between disease onset and diagnosis is mainly 10 years due to progressive chronic evolution and exposure to high levels of GH and IGF-1. Here we present a case of acromegaly with over 25 years of diagnostic delay in 69-years-old male with typical features and recurrent urolithiasis. Biochemical diagnosis was confirmed by high levels of IGF-1and lack of suppression of GH during an oral glucose load. Imaging and histological study revealed a co-secreting GH/ prolactine macroadenoma. After three months of complete transphenoidal surgical resection, biochemical remission was not obtained and the patient was treated by a somatostatin receptor ligand. Based on this severe case with atypical manifestations, the diagnosis of acromegaly should be always considered.

肢端肥大症:一种后果严重的内分泌病理
肢端肥大症是一种罕见的内分泌疾病,可导致后天性畸形和多系统损伤。95%以上的病例是由垂体腺瘤引起的。从发病到诊断的潜伏期主要是10年,这是由于慢性进展和暴露于高水平的生长激素和IGF-1。我们在此报告一位69岁男性肢端肥大症患者,诊断延迟超过25年,具有典型特征和复发性尿石症。在口服葡萄糖负荷期间,高水平的igf -1和缺乏生长激素抑制证实了生化诊断。影像学和组织学研究显示一个共分泌GH/泌乳素的大腺瘤。经蝶窦手术切除3个月后,患者未获得生化缓解,改用生长抑素受体配体治疗。基于这一严重病例的不典型表现,应始终考虑肢端肥大症的诊断。
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来源期刊
Annales de biologie clinique
Annales de biologie clinique 医学-医学:研究与实验
CiteScore
0.80
自引率
20.00%
发文量
53
审稿时长
6-12 weeks
期刊介绍: Multidisciplinary information with direct relevance to everyday practice Annales de Biologie Clinique, the official journal of the French Society of Clinical Biology (SFBC), supports biologists in areas including continuing education, laboratory accreditation and technique validation. With original articles, abstracts and accounts of everyday practice, the journal provides details of advances in knowledge, techniques and equipment, as well as a forum for discussion open to the entire community.
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