Plants and endophytes - a partnership for the coumarin production through the microbial systems.

IF 4.6 2区 生物学 Q1 MYCOLOGY
Mycology Pub Date : 2022-02-07 eCollection Date: 2022-01-01 DOI:10.1080/21501203.2022.2027537
Chandrashekar Srinivasa, Govindappa Mellappa, Shashank M Patil, Ramith Ramu, Bhargav Shreevatsa, Chandan Dharmashekar, Shiva Prasad Kollur, Asad Syed, Chandan Shivamallu
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引用次数: 12

Abstract

Plant-based secondary metabolite production system is well established. However, host-endophyte interaction in the production of secondary metabolite is a new less exploited area that is overcoming barriers and evolving as one of the prospective fields. Endophytes such as bacteria or fungi have the ability to produce some of the secondary metabolites that mimic the plant metabolites therefore escaping the host defence system. Coumarin is one such metabolite with immense biological functions. Most of the studies have demonstrated coumarin production from fungal endophytes but not bacterial endophytes. Herein, we present an overview of all the coumarin derivatives produced from endophytic sources and their biosynthetic pathways. Furthermore, the review also throws light on the isolation of these coumarins and different derivatives with respect to their biological activity. The biotransformation of coumarin derivatives by the action of endophytic fungi is also elaborated. The present review provides an insight on the challenges faced in the coumarin production through fungal endophytes.

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植物和内生菌——通过微生物系统生产香豆素的伙伴关系。
以植物为基础的次生代谢物生产体系已经建立。然而,宿主-内生菌相互作用在次生代谢物产生中的作用是一个新的开发较少的领域,正在克服障碍,发展成为一个有前景的领域之一。细菌或真菌等内生菌有能力产生一些模仿植物代谢物的次生代谢物,从而逃脱宿主的防御系统。香豆素就是这样一种具有巨大生物学功能的代谢物。大多数研究表明,香豆素是由真菌内生菌产生的,而不是细菌内生菌。在这里,我们介绍了所有的香豆素衍生物产生的内生来源和他们的生物合成途径的概述。此外,本文还对这些香豆素及其衍生物的分离及其生物活性进行了综述。并对香豆素衍生物在内生真菌作用下的生物转化进行了阐述。本文综述了真菌内生菌生产香豆素所面临的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Mycology
Mycology Medicine-Infectious Diseases
CiteScore
9.10
自引率
0.00%
发文量
18
审稿时长
13 weeks
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