Triglyceride-to-glucose index to detect a non-dipping circadian pattern in newly diagnosed hypertensive patients.

IF 1.2 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Faysal Şaylık, Tufan Çınar, Murat Selçuk, Tayyar Akbulut
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引用次数: 1

Abstract

Introduction: In this investigation, we aimed to explore the relationship between the triglyceride-glucose (TyG) index and the non-dipping blood pressure (BP) pattern in newly diagnosed hypertensive patients. Methods: In this retrospective study, 216 consecutive newly diagnosed hypertensive patients who had undergone 24-hour ambulatory blood pressure (ABPM) monitoring and had not received anti-hypertensive drugs were included. Non-dipping status was evaluated by a 24-h ABPM monitoring in all patients. We categorized the patients into two groups as; dippers (n=104 cases) and non-dippers (n=112 cases). The TyG index was derived from the fasting triglyceride and fasting glucose levels using the formula; ln[fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Results: Non-dipper group had a higher TyG index than the dipper group. The TyG was an independent predictor of non-dipping BP in hypertensive individuals, according to multivariable analysis. The TyG index was negatively associated with a decrease in both systolic and diastolic BP during the nighttime. The ideal cutoff value of the TyG index in detecting non-dipping status was≥9.01 with 74.1% sensitivity and 71.2% specificity. A ROC comparison indicated that the area under the curve value of TyG index was superior to fasting triglyceride, fasting glucose, and homeostasis model assessment of IR (HOMA-IR) in detecting non-dipping BP. Conclusion: The TyG index was an independent predictor of non-dipping status in newly diagnosed hypertensive patients who had undergone 24-hour ABPM monitoring and had not received anti-hypertensive drugs. As a simple and easily obtained parameter, the TyG index can be used to detect such pattern among these patients.

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甘油三酯-葡萄糖指数检测新诊断高血压患者的非倾斜昼夜节律模式。
前言:本研究旨在探讨新诊断高血压患者的甘油三酯-葡萄糖(TyG)指数与不降血压(BP)模式的关系。方法:回顾性研究216例连续接受24小时动态血压(ABPM)监测且未接受降压药治疗的新诊断高血压患者。所有患者均通过24小时ABPM监测来评估非浸入状态。我们将患者分为两组:舀水者(104例)和非舀水者(112例)。TyG指数由空腹甘油三酯和空腹血糖水平得出,使用公式;ln[空腹甘油三酯(mg/dL) ×空腹葡萄糖(mg/dL)/2]。结果:未翻斗组TyG指数高于翻斗组。根据多变量分析,TyG是高血压患者血压不下降的独立预测因子。TyG指数与夜间收缩压和舒张压的降低呈负相关。TyG指数检测非浸渍状态的理想临界值≥9.01,敏感性74.1%,特异性71.2%。ROC比较表明,TyG指数曲线值下面积优于空腹甘油三酯、空腹血糖和IR稳态模型评估(HOMA-IR)检测非下沉血压。结论:TyG指数可作为24小时ABPM监测、未服用降压药的新诊断高血压患者不降血压状态的独立预测指标。TyG指数作为一个简单且容易获得的参数,可以用来检测这些患者的这种模式。
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来源期刊
Journal of Cardiovascular and Thoracic Research
Journal of Cardiovascular and Thoracic Research CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.00
自引率
0.00%
发文量
22
审稿时长
7 weeks
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