Possible different genotypes for human papillomavirus vaccination in lower middle-income countries towards cervical cancer elimination in 2030: a cross-sectional study.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2022-05-01 Epub Date: 2022-05-31 DOI:10.7774/cevr.2022.11.2.141
Tofan Widya Utami, Andrijono Andrijono, Andi Putra, Junita Indarti, Gert Fleuren, Ekaterina Jordanova, Inas Humairah, Ahmad Utomo
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引用次数: 0

Abstract

Purpose: Human papillomavirus (HPV) genotype and age distribution of HPV infection were crucial for the national vaccination and screening program planning. However, there was a limited study providing these data in the normal cervix population. This study aimed to explore the HPV genotypes profile of women with clinically normal cervix based on Visual Inspection of Acetic Acid (VIA) test.

Materials and methods: A 7-year cross-sectional study was conducted from 2012 to 2018 in private and public health care centers in Jakarta. Subjects were recruited consecutively. Data were collected by anamnesis, VIA, and HPV DNA test using the polymerase chain reaction (PCR; SPF10-DEIA-LiPA25) method. HPV genotyping procedures include DNA extraction, PCR (SPF10-DEIA-LiPA25) using the HPV XpressMatrix kit (PT KalGen DNA, East Jakarta, Indonesia), and hybridization. The IBM SPSS ver. 20.0 (IBM Corp., Armonk, NY, USA) were used to analyze the data.

Results: A total of 1,397 subjects were collected. Positive HPV-DNA tests were found in 52 subjects (3.7%); 67% were single and 33% were multiple HPV infections. HPV 52 was the most frequently detected HPV genotype, followed by HPV 39, 16, 18 74, 44, 31, 54, and 66, respectively. The highest HPV infections in this population were in the 31-40 and 41-50 years old group.

Conclusion: This study suggested beneficial screening for women aged 31-50 years old. Instead of "original" nonavalent (HPV 16, 18, 6, 11, 31, 33, 45, 52, 58), the different "nonavalent" formula for HPV vaccines protecting against HPV 16, 18, 6, 11, 31, 39, 44, 52, 74 might be useful for Indonesian population. However, further multicenter studies with a huge sample size are still needed.

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在中低收入国家实现2030年消除宫颈癌的人类乳头瘤病毒疫苗接种的可能不同基因型:一项横断面研究。
目的:人乳头瘤病毒(HPV)的基因型和年龄分布对国家疫苗接种和筛查规划具有重要意义。然而,在正常子宫颈人群中提供这些数据的研究有限。本研究旨在探讨临床宫颈正常妇女的HPV基因型,基于醋酸目视检查(VIA)试验。材料和方法:2012年至2018年,在雅加达的私人和公共卫生保健中心进行了一项为期7年的横断面研究。受试者被连续招募。通过记忆、VIA和HPV DNA检测收集数据,采用聚合酶链反应(PCR;SPF10-DEIA-LiPA25)方法。HPV基因分型程序包括DNA提取,使用HPV XpressMatrix试剂盒(PT KalGen DNA, East Jakarta, Indonesia)进行PCR (SPF10-DEIA-LiPA25)和杂交。IBM SPSS软件。20.0 (IBM Corp., Armonk, NY, USA)进行数据分析。结果:共收集1397名受试者。HPV-DNA检测阳性52例(3.7%);67%为单一HPV感染,33%为多重HPV感染。HPV 52是最常见的HPV基因型,其次是HPV 39、16、18 74、44、31、54和66。该人群中HPV感染率最高的是31-40岁和41-50岁年龄组。结论:本研究建议对31-50岁的女性进行有益的筛查。替代“原始”非价型(HPV 16、18、6、11、31、33、45、52、58),不同的“非价型”HPV疫苗配方保护HPV 16、18、6、11、31、39、44、52、74可能对印度尼西亚人口有用。然而,仍需要进一步的多中心大样本量研究。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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