A Study to Improve the Vitamin A and Iodine Status of Pregnant Women through a Multiple Micronutrient Fortified Salt.

IF 2.3 Q3 NUTRITION & DIETETICS
Journal of Nutrition and Metabolism Pub Date : 2022-11-10 eCollection Date: 2022-01-01 DOI:10.1155/2022/5301499
Malavika Vinod Kumar, M Sankarapandian, Juergen Erhardt
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引用次数: 0

Abstract

Background: To study the efficacy of a multiple micronutrient fortified salt enriched with iron, iodine, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, and folic acid in improving serum retinol and iodine status of pregnant women.

Methods: It was a randomized control trial in the antenatal clinic of a hospital. 151 women in the experimental group received a multiple micronutrient fortified salt to cook all their meals, and 150 women in the control group did not receive the fortified salt. Blood was collected in the three trimesters. Urine was collected in their first and third trimesters. Serum retinol, CRP (C-reactive protein), and AGP (Alpha glycoprotein) in blood were assessed, and iodine was assessed in urine. All the women were dewormed once.

Results: The inflammation adjusted mean serum retinol in three trimesters in the experimental group was 24.51, 27.29, and 25.68 µg/dL, and it was 28.97, 27.63, and 22.72 µg/dL in the control group. Over the study period of 6 months, the increase in serum retinol in the experimental group was 1.17 µg/dL whereas in the control group serum retinol decreased by 6.25 µg/dL. The experimental group increase in serum retinol is significantly more (p=0.0001) than the changes in retinol in the control group. The prevalence of serum retinol deficiency in the three trimesters was 39.1%,25.8%, and 37.7% in the experimental group and 14%, 22.7%, and 39.3% in the control group, and the change in the experimental group was significant (p=0.001) compared to the control group by binary logistic regression. Over the study period of 6 months there is a significant increase in urinary iodine concentration in the experimental group (p=0.030), showing absorption of iodine from the fortified salt whereas there is a significant decline in the iodine values in the control group (p=0.008). At the end of the study, the urinary iodine concentration of the experimental group was significantly more (p=0.0001) than that of the control group.

Conclusion: The fortified salt was able to improve serum retinol levels and urinary iodine levels in pregnant women. Trial Registration. This trial was registered retrospectively on 19/02/2022 in the ISRCTN registry with trial ID ISRCTN17782574.

通过多种微量元素强化盐改善孕妇维生素A和碘水平的研究。
背景:研究富含铁、碘、维生素a、维生素B1、维生素B2、维生素B6、维生素B12、烟酸和叶酸的复合微量营养素强化盐对孕妇血清视黄醇和碘水平的改善作用。方法:在某医院产前门诊进行随机对照试验。实验组的151名女性在烹饪时都摄入了多种微量营养素强化盐,而对照组的150名女性则没有摄入强化盐。在妊娠三个月采集血液。在妊娠早期和晚期收集尿液。测定血清视黄醇、c反应蛋白(CRP)和α糖蛋白(AGP),测定尿碘。所有的女人都被除了一次虫。结果:试验组3个月炎症调整后血清视黄醇均值分别为24.51、27.29、25.68µg/dL,对照组为28.97、27.63、22.72µg/dL。在6个月的研究期间,实验组的血清视黄醇增加了1.17µg/dL,而对照组的血清视黄醇减少了6.25µg/dL。实验组血清视黄醇的升高明显高于对照组(p=0.0001)。试验组妊娠3个月血清视黄醇缺乏率分别为39.1%、25.8%、37.7%,对照组为14%、22.7%、39.3%,经二元logistic回归分析,试验组与对照组比较差异有统计学意义(p=0.001)。在6个月的研究期间,实验组的尿碘浓度显著增加(p=0.030),表明从强化盐中吸收了碘,而对照组的碘值则显著下降(p=0.008)。研究结束时,实验组尿碘浓度显著高于对照组(p=0.0001)。结论:强化盐能提高孕妇血清视黄醇水平和尿碘水平。试验注册。该试验于2022年2月19日在ISRCTN注册中心回顾性注册,试验ID为ISRCTN17782574。
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来源期刊
Journal of Nutrition and Metabolism
Journal of Nutrition and Metabolism NUTRITION & DIETETICS-
CiteScore
5.40
自引率
0.00%
发文量
49
审稿时长
17 weeks
期刊介绍: Journal of Nutrition and Metabolism is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering the broad and multidisciplinary field of human nutrition and metabolism. The journal welcomes submissions on studies related to obesity, diabetes, metabolic syndrome, molecular and cellular biology of nutrients, foods and dietary supplements, as well as macro- and micronutrients including vitamins and minerals.
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