Hormonal contraceptive usage influences stress hormone effects on cognition and emotion

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Frontiers in Neuroendocrinology Pub Date : 2022-10-01 DOI:10.1016/j.yfrne.2022.101012

Valerie L. Jentsch, Lisa Pötzl, Oliver T. Wolf , Christian J. Merz

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引用次数: 17

Abstract

Men and women partially differ in how they respond to stress and how stress in return affects their cognition and emotion. The influence of hormonal contraceptives (HCs) on this interaction has received little attention, which is surprising given the prevalence of HC usage. This selective review illustrates how HC usage modulates the effects of stress hormones on cognition and emotion. As three examples, we discuss stress hormone effects on episodic memory, fear conditioning and cognitive emotion regulation. The identified studies revealed that stress effects on cognitive-emotional processes in women using HCs were at times reduced or even absent when compared to men or naturally cycling women. Especially striking were the few examples of reversed effects in HC women. As underlying neuroendocrine mechanisms, we discuss influences of HCs on the neuroendocrine stress response and effects of HCs on central glucocorticoid sensitivity. The summarized findings emphasize the need for additional translational research.

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激素避孕药的使用影响应激激素对认知和情绪的影响

男性和女性在如何应对压力以及压力如何影响他们的认知和情感方面存在部分差异。激素避孕药(HC)对这种相互作用的影响很少受到关注，这是令人惊讶的，因为HC的使用很普遍。这篇选择性的综述说明了HC的使用如何调节应激激素对认知和情绪的影响。作为三个例子，我们讨论了应激激素对情景记忆、恐惧条件反射和认知情绪调节的影响。已确定的研究表明，与男性或自然循环的女性相比，使用hc的女性的压力对认知-情绪过程的影响有时会减少甚至没有。尤其引人注目的是，在HC女性中出现了一些逆转效应的例子。作为潜在的神经内分泌机制，我们讨论了hc对神经内分泌应激反应的影响以及hc对中枢糖皮质激素敏感性的影响。总结的结果强调需要进一步的转化研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.