Determination of the Unilaterally Damaged Region May Depend on the Asymmetry of Carotid Blood Flow Velocity in Hemiparkinsonian Monkey: A Pilot Study.

IF 2.2 4区 医学 Q3 CLINICAL NEUROLOGY
Parkinson's Disease Pub Date : 2022-11-09 eCollection Date: 2022-01-01 DOI:10.1155/2022/4382145
Jincheol Seo, Kyung Seob Lim, Chang-Yeop Jeon, SeungHo Baek, Hyeon-Gu Yeo, Won Seok Choi, Sung-Hyun Park, Kang Jin Jeong, Jinyoung Won, Keonwoo Kim, Junghyung Park, Jiyeon Cho, Jung Bae Seong, Minji Kim, Yu Gyeong Kim, Jae-Won Huh, Samhwan Kim, Yong Hoon Lim, Hyung Woo Park, Hye Min Tak, Man Seong Heo, Ji-Woong Choi, Sun Ha Paek, Youngjeon Lee
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引用次数: 0

Abstract

The hemiparkinsonian nonhuman primate model induced by unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the carotid artery is used to study Parkinson's disease. However, there have been no studies that the contralateral distribution of MPTP via the cerebral collateral circulation is provided by both the circle of Willis (CoW) and connections of the carotid artery. To investigate whether MPTP-induced unilaterally damaged regions were determined by asymmetrical cerebral blood flow, the differential asymmetric damage of striatal subregions, and examined structural asymmetries in a circle of Willis, and blood flow velocity of the common carotid artery were observed in three monkeys that were infused with MPTP through the left internal carotid artery. Lower flow velocity in the ipsilateral common carotid artery and a higher ratio of ipsilateral middle cerebral artery diameter to anterior cerebral artery diameter resulted in unilateral damage. Additionally, the unilateral damaged monkey observed the apomorphine-induced contralateral rotation behavior and the temporary increase of plasma RANTES. Contrastively, higher flow velocity in the ipsilateral common carotid artery was observed in the bilateral damaged monkey. It is suggested that asymmetry of blood flow velocity and structural asymmetry of the circle of Willis should be taken into consideration when establishing more efficient hemiparkinsonian nonhuman primate models.

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判断单侧受损区域可能依赖于偏帕金森猴颈动脉血流速度的不对称性:一项初步研究。
采用单侧颈动脉注射1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的偏帕金森非人灵长类动物模型研究帕金森病。然而,没有研究表明MPTP通过脑侧支循环的对侧分布是由威利斯环(CoW)和颈动脉连接提供的。为了探讨MPTP诱导的单侧损伤区域是否由脑血流不对称决定,对3只经左颈内动脉注入MPTP的猴子进行纹状体亚区差异不对称损伤,观察威氏圈结构不对称,观察颈总动脉血流速度。同侧颈总动脉流速较低,同侧大脑中动脉直径与大脑前动脉直径之比较高,导致单侧损伤。此外,单侧损伤猴观察到阿吗啡诱导的对侧旋转行为和血浆RANTES暂时性升高。相比之下,双侧受损猴子的同侧颈总动脉流速更高。建议在建立更有效的半帕金森非人灵长类动物模型时,应考虑血流速度的不对称性和威利斯圈结构的不对称性。
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来源期刊
Parkinson's Disease
Parkinson's Disease CLINICAL NEUROLOGY-
CiteScore
5.80
自引率
3.10%
发文量
0
审稿时长
18 weeks
期刊介绍: Parkinson’s Disease is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinson’s disease.
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