Outcomes from Individual Alpha Frequency Guided Repetitive Transcranial Magnetic Stimulation in Children with Autism Spectrum Disorder - A Retrospective Chart Review.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-08-01 Epub Date: 2022-11-11 DOI:10.1007/s10578-022-01461-1

Uchenna Ezedinma, Piotr Swierkowski, Shauna Fjaagesund

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引用次数: 0

Abstract

Aims and objectives: Individual alpha frequency (IAF) is a biomarker of neurophysiological functioning. The IAF-guided repetitive transcranial magnetic stimulation (α-rTMS) is increasingly explored in diverse neurological conditions. However, there is limited data on the efficacy and safety of α-rTMS in children with autism spectrum disorder (ASD).

Materials and methods: The IAF, childhood autism rating scale (CARS), Pediatric Quality of Life Inventory 4.0 (PedsQLTM 4.0), and semi-structured interview data of patients that received 19 α-rTMS sessions (4 weeks) were aggregated and analysed using paired student t-test and descriptive method.

Results: Data were retrieved from 28 patients (26 males, aged 3-9years (mean ± SD age: 6.1 ± 1.8years)). The post-α-rTMS data shows a significant improvement in IAF (9.4 Hz; p ≤ 0.025) towards 10 Hz. The CARS and PedsQLTM 4.0 surveys indicate that patients' ASD symptoms and quality of life improved significantly. Specifically, reports from semi-structured interviews suggest improved sleep trouble - the most significant comorbidity. The experiences of minor side effects such as hyperactivity resolved within two hours following α-rTMS sessions.

Conclusion: This study presents evidence on the efficacy and safety of α-rTMS in improving ASD symptoms, quality of life and comorbid sleep troubles in children. However, these findings should be interpreted as preliminary pending the presentation of double-blind, randomised clinical trials.

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自闭症谱系障碍儿童在个体阿尔法频率引导下接受重复经颅磁刺激的结果--回顾性病历审查。

目的和目标：个体α频率（IAF）是神经生理功能的生物标志物。在 IAF 引导下的重复经颅磁刺激（α-rTMS）越来越多地被用于治疗各种神经系统疾病。然而，有关α-rTMS对自闭症谱系障碍（ASD）儿童的疗效和安全性的数据却很有限：采用配对学生 t 检验和描述性方法对接受 19 次 α-rTMS 治疗（4 周）的患者的 IAF、儿童自闭症评分量表（CARS）、儿科生活质量量表 4.0（PedsQLTM 4.0）和半结构式访谈数据进行汇总和分析：从 28 名患者（26 名男性，年龄为 3-9 岁（平均 ± SD 年龄：6.1 ± 1.8 岁））处获得了数据。α-经颅磁刺激后的数据显示，IAF（9.4 Hz；p ≤ 0.025）向 10 Hz 方向有明显改善。CARS 和 PedsQLTM 4.0 调查显示，患者的 ASD 症状和生活质量有了明显改善。特别是，半结构式访谈报告显示，睡眠问题--最重要的合并症--得到了改善。在α-经颅磁刺激治疗后的两小时内，多动等轻微副作用也得到了缓解：本研究提供了α-经颅磁刺激疗法在改善儿童自闭症症状、生活质量和合并睡眠障碍方面的有效性和安全性的证据。然而，在双盲、随机临床试验提出之前，这些研究结果应被视为初步结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.