Correlation between α-synuclein and fatty acid composition in jejunum of rotenone-treated mice is dependent on acyl chain length.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-11-01 DOI:10.4149/gpb_2022046

Dominika Hajduchova, Roman Holic, Peter Gajdos, Milan Certik, Erika Halasova, Renata Pecova, Michal Pokusa

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引用次数: 0

Abstract

Events associated with the progression of Parkinson´s disease (PD) are closely related to biomembrane dysfunction. The specific role of membrane composition in the conformational stability of alpha synuclein (αS) has already been well documented. Administration of rotenone is one of the best strategies to initiate PD phenotype in animal models. In the present study, daily exposure (14 weeks) of orally administered rotenone (10 mg/kg) was employed in a mouse model. The mitochondrial complex I inhibition resulted in elevated level of αS in whole tissue homogenate of mouse jejunum. In addition, we identified a strong intra-individual correlation between αS level and the specific esterified fatty acids. The observed correlation depends mainly on the acyl chain length. Based on the obtained results, it is suggested that there is a high potential to manipulate fatty acid homeostasis in modulating αS based pathogenesis of PD, at least in experimental conditions.

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鱼藤酮处理小鼠空肠α-突触核蛋白与脂肪酸组成的相关性与酰基链长度有关。

与帕金森病(PD)进展相关的事件与生物膜功能障碍密切相关。膜组成在α -突触核蛋白(αS)构象稳定性中的特殊作用已经得到了很好的证明。在动物模型中，给予鱼藤酮是启动PD表型的最佳策略之一。在本研究中，小鼠模型采用每日口服鱼藤酮(10 mg/kg)暴露(14周)。线粒体复合体I抑制导致小鼠空肠全组织匀浆αS水平升高。此外，我们还发现αS水平与特定的酯化脂肪酸之间存在很强的个体内相关性。观察到的相关性主要取决于酰基链的长度。基于所获得的结果，表明至少在实验条件下，在调节αS为基础的PD发病机制中，有很高的潜力操纵脂肪酸稳态。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.