What psammoma bodies can represent in the thyroid. What we recently learnt from a story of lack of evidence.

IF 4.4 Q1 PATHOLOGY
PATHOLOGICA Pub Date : 2022-10-01 DOI:10.32074/1591-951X-815
Lina Cardisciani, Federica Policardo, Pietro Tralongo, Vincenzo Fiorentino, Esther Diana Rossi
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引用次数: 3

Abstract

The detection of psammoma bodies (PBs) in the thyroid gland is commonly associated to classic papillary thyroid carcinoma (PTC) and are frequently encountered in differnt subtypes of PTCs. Nonetheless, the evidence of PBs without a PTC may represent a diagnostic challenge. The general statement is that PBs represent a metastatic finding of PTC either when encountered inside the thyroid parenchyma or in the perithyroidal lymph nodes. The majority of authors assess that in presence of PBs, a search for an occult PTC is strongly encouraged and mandatory, especially if a lobectomy had been performed. In fact, it is not uncommon that a contralateral or ipsilateral tumor, mostly PTC, is found leading to the suggestion that the best recommendation is to submit the entire thyroid tissue. Nonetheless, when a cancer has not been found, the possibility of the rare evenience that PBs are likely to be associated with benign conditions should be considered among the differential diagnosis. Herein a short commentary and review of the literature on PBs detection and its diagnosis, based on our recent experience.

Abstract Image

Abstract Image

沙粒体在甲状腺中的表现。我们最近从一个缺乏证据的故事中学到了什么。
甲状腺沙粒小体(PBs)的检测通常与典型的甲状腺乳头状癌(PTC)相关,并且经常出现在不同亚型的PTC中。尽管如此,无PTC的PBs证据可能是一种诊断挑战。一般的说法是,当遇到甲状腺实质内或甲状腺周围淋巴结时,PBs代表PTC的转移发现。大多数作者评估,在PBs存在的情况下,强烈鼓励和强制搜索隐匿性PTC,特别是如果已经进行了肺叶切除术。事实上,发现对侧或同侧肿瘤(主要是PTC)并不罕见,因此建议最好的建议是提交整个甲状腺组织。尽管如此,当尚未发现癌症时,在鉴别诊断中应考虑PBs可能与良性疾病相关的罕见可能性。本文根据我们最近的经验,对PBs检测及其诊断的文献进行简短的评论和回顾。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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