[Influence of intranasally administered insulin on metabolic and hormonal parameters in adult male rats, impaired due to three-day fasting in the early postnatal period].

Q3 Biochemistry, Genetics and Molecular Biology
K V Derkach, V M Bondareva, A O Shpakov
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引用次数: 1

Abstract

Temporary cessation or restriction of breastfeeding can lead to metabolic disorders in adulthood. However, data on the effect of fasting in the early postnatal period on the functions of the endocrine system in adulthood are rare and contradictory. Approaches for the correction of metabolic and hormonal disorders caused by premature cessation of breastfeeding have not been developed yet. The aim of the work was to study the metabolic and hormonal parameters and changes in the hormonal status of the gonadal and thyroid systems in 10-month-old male rats with interruption of breastfeeding on days P19-P21, as well as to evaluate the restorative effect on them of four weeks of treatment with intranasal insulin (II) administered in the postnatal period (P28-P55) or in adulthood (P183-P210). Lactation interruption has been induced by treatment of lactating females with bromocriptine (10 mg/day/rat, P19-P21). Male rats with temporary cessation of breastfeeding developed characteristic signs of the metabolic syndrome (obesity, dyslipidemia, impaired glucose tolerance, hyperleptinemia), decreased levels of testosterone and thyroid hormones (fT4, tT3) and weakened the synthesis of testosterone and thyroxine, stimulated respectively by GnRH and thyroliberin. This was due to a decrease in the sensitivity of the testes to luteinizing hormone (LH) and the thyroid gland to thyroid-stimulating hormone (TSH). Treatment with II in early ontogenesis reduced body weight and fat, improved lipid profile, sensitivity to insulin, leptin, LH and TSH, restored the levels of testosterone and thyroid hormones and their stimulation by releasing factors. Treatment with II in adulthood normalized the levels of testosterone, thyroid hormones, their stimulation by releasing factors, but had a little effect on metabolic and hormonal parameters. The obtained data point to a wide range of metabolic and hormonal disorders in adult male rats with the "neonatal" model of metabolic syndrome and to the effectiveness of various strategies for their correction using long-term II treatment.

[鼻内注射胰岛素对成年雄性大鼠代谢和激素参数的影响,这些大鼠因产后早期禁食三天而受损]。
暂时停止或限制母乳喂养可导致成年期代谢紊乱。然而,关于产后早期禁食对成年期内分泌系统功能影响的数据很少且相互矛盾。纠正因过早停止母乳喂养而引起的代谢和激素紊乱的方法尚未开发。本研究的目的是研究10月龄雄性大鼠在P19-P21天中断母乳喂养时的代谢和激素参数以及性腺和甲状腺系统激素状态的变化,并评估在产后(P28-P55)或成年期(P183-P210)给予4周鼻内胰岛素(II)治疗对它们的恢复作用。哺乳期雌性用溴隐亭(10 mg/天/只,P19-P21)治疗可导致泌乳中断。暂时停止母乳喂养的雄性大鼠出现代谢综合征的特征性症状(肥胖、血脂异常、糖耐量下降、高瘦素血症),睾酮和甲状腺激素(fT4、tT3)水平下降,GnRH和促甲状腺素分别刺激睾酮和甲状腺素的合成减弱。这是由于睾丸对黄体生成素(LH)和甲状腺对促甲状腺激素(TSH)的敏感性降低。在个体发育早期使用II治疗可降低体重和脂肪,改善血脂,改善对胰岛素、瘦素、LH和TSH的敏感性,恢复睾酮和甲状腺激素的水平及其释放因子的刺激。成年期II治疗使睾酮、甲状腺激素及其释放因子的刺激水平正常化,但对代谢和激素参数影响不大。获得的数据指向代谢综合征“新生儿”模型成年雄性大鼠的广泛代谢和激素紊乱,以及使用长期II治疗对其进行纠正的各种策略的有效性。
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来源期刊
Biomeditsinskaya khimiya
Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.30
自引率
0.00%
发文量
49
期刊介绍: The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).
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