Present Evidence of Determinants to Predict the Efficacy of Renal Denervation.

IF 1.9 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
International Journal of Hypertension Pub Date : 2022-08-12 eCollection Date: 2022-01-01 DOI:10.1155/2022/5694127
Hao Zhou, Yanping Xu, Weijie Chen, Liang Wang, Huaan Du, Hang Liu, Zhiyu Ling, Yuehui Yin
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引用次数: 3

Abstract

Sympathetic overactivation is one of the main contributors to development and progress of hypertension. Renal denervation (RDN) has been evidenced by series of clinical trials for its efficacy and safety to treat overactivated sympathetic nervous system induced diseases. However, the results were inconsistent and not all patients benefited from RDN. Appropriate patient selection and intraoperative factors to improve the efficacy of RDN need to be solved urgently. Over the decade, research studies on the correlations between indicators and the antihypertensive effects have been conducted and made a fairly well progress. Herein, we comprehensively reviewed the research studies on how to make RDN more predictable or improve the efficacy of RDN and summarized these potential indicators or devices which might be applied in clinical settings.

预测肾去神经支配疗效的决定因素的证据。
交感神经过度激活是高血压发生发展的主要因素之一。肾去神经支配治疗交感神经系统过度激活性疾病的有效性和安全性已被一系列临床试验所证实。然而,结果并不一致,并非所有患者都受益于RDN。合理的患者选择和术中因素是提高RDN疗效的迫切需要解决的问题。近十年来,有关指标与降压效果相关性的研究已经开展,并取得了较好的进展。在此,我们对如何提高RDN的可预测性或提高RDN的疗效的研究进行了全面的综述,并总结了这些可能在临床应用的潜在指标或设备。
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来源期刊
International Journal of Hypertension
International Journal of Hypertension Medicine-Internal Medicine
CiteScore
4.00
自引率
5.30%
发文量
45
期刊介绍: International Journal of Hypertension is a peer-reviewed, Open Access journal that provides a forum for clinicians and basic scientists interested in blood pressure regulation and pathophysiology, as well as treatment and prevention of hypertension. The journal publishes original research articles, review articles, and clinical studies on the etiology and risk factors of hypertension, with a special focus on vascular biology, epidemiology, pediatric hypertension, and hypertensive nephropathy.
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