The preparation of novel AIE fluorescent microspheres by dispersion polymerization.

IF 2.4 4区化学 Q3 POLYMER SCIENCE

Designed Monomers and Polymers Pub Date : 2022-06-13 eCollection Date: 2022-01-01 DOI:10.1080/15685551.2022.2088969

Hui Wang, Zhizhou Liu, Xueyan Nan, Tong Wang, Xuming Sun, Liang He, Pengli Bai

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Abstract

An approach to prepare monodisperse polystyrene microspheres with aggregation-induced emission (AIE) characteristics has been developed which shows promising applications in fluorescence-encoding. The micron-sized, monodisperse polystyrene microspheres with AIE molecules were perfectly synthesized by two-stage dispersion polymerization. Fluorescent AIE monomer was synthesized by Suzuki reaction, confirmed by nuclear magnetic resonance (NMR). These AIE fluorogens (AIEgens) exhibited unique properties such as bright green emission in solid state and increased emission in tetrahydrofuran (THF) solution with the increase of water content. The influence of the AIE molecules concentration to microspheres synthesis was well investigated. The reaction conditions were optimized to obtain the functional polystyrene microspheres with a size distribution around 3%. The novel microspheres were characterized by scanning electron microscopy (SEM), confocal fluorescence microscope and flow cytometry. According to these results, two-stage dispersion polymerization was proved to be an efficient pathway for the preparation of AIE fluorescent and functionalized microspheres, which could be used in many biomedical industries.

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分散聚合法制备新型AIE荧光微球。

研究了一种具有聚集致发射特性的单分散聚苯乙烯微球的制备方法，该方法在荧光编码中具有良好的应用前景。采用两段分散聚合法制备了具有AIE分子的微米级单分散聚苯乙烯微球。采用Suzuki反应合成了AIE荧光单体，并经核磁共振证实。这些AIE氟化物(AIEgens)在固体状态下具有亮绿色发光，在四氢呋喃(THF)溶液中随含水量的增加而增加发光。研究了AIE分子浓度对微球合成的影响。优化了反应条件，得到了粒径分布在3%左右的功能聚苯乙烯微球。采用扫描电镜、共聚焦荧光显微镜和流式细胞术对微球进行了表征。结果表明，两段分散聚合是制备AIE荧光微球和功能化微球的有效途径，可用于生物医药行业。

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来源期刊

Designed Monomers and Polymers 化学-高分子科学

CiteScore

3.30

自引率

0.00%

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审稿时长

2.1 months

期刊介绍： Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications

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(4-vinylphenyl) boronic acid
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