The socially enriched environment test: a new approach to evaluate social behavior in a mouse model of social anxiety disorder.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2022-10-17 Print Date: 2022-11-01 DOI:10.1101/lm.053627.122
Zineb Boudjafad, Asmae Lguensat, Kenza Elmardadi, Asma Dahi, Mohamed Bennis, Saadia Ba-M'hamed, René Garcia
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引用次数: 0

Abstract

Social anxiety disorder (SAD) is a common anxiety disorder characterized by a marked fear of social situations. Treatments for SAD, including exposure therapy and medication, are not satisfactory for all patients. This has led to the development of several paradigms to study social fear in rodents. However, there are still some social impairments observed in SAD patients that have never been examined in rodent models. Indeed, social situations avoided by SAD patients include not only social interactions but also public performances and being observed by others. Nevertheless, tests used to assess sociability in rodents evaluate mostly social interaction in pairs. Thus, we developed a new test-a socially enriched environment test-that evaluates sociability within a group of three unfamiliar conspecifics in an enriched environment. In this study, we induced a SAD-like behavior (i.e., social fear) in male mice using social fear conditioning (SFC) and then tested social fear using the socially enriched environment test and the three-chamber test. Finally, we tested the effects of fear extinction and acute diazepam treatment in reversing social fear. Results revealed, in conditioned mice, decreased object exploration in proximity to conspecifics, social interaction, and mouse-like object exploration. Extinction training, but not acute diazepam treatment, reversed SFC-induced behavioral changes. These findings demonstrate that the socially enriched environment test provides an appropriate behavioral approach to better understand the etiology of SAD. This test may also have important implications in the exploration of new treatments.

社交丰富环境测试:在社交焦虑症小鼠模型中评估社交行为的一种新方法。
社交焦虑症(SAD)是一种常见的焦虑症,其特征是对社交环境的明显恐惧。SAD的治疗,包括暴露治疗和药物治疗,并不是所有患者都满意。这导致了研究啮齿类动物社会恐惧的几种范式的发展。然而,在SAD患者中仍然观察到一些从未在啮齿动物模型中检查过的社会障碍。事实上,SAD患者避免的社交场合不仅包括社交互动,还包括公共表演和被他人观察。然而,用于评估啮齿动物社交能力的测试主要评估成对的社交互动。因此,我们开发了一种新的测试——一种社会丰富的环境测试,用于评估三个不熟悉的同种动物在丰富的环境中的社交能力。在这项研究中,我们使用社会恐惧条件反射(SFC)在雄性小鼠中诱导了类似SAD的行为(即社会恐惧),然后使用社会富集环境测试和三室测试来测试社会恐惧。最后,我们测试了消除恐惧和急性安定治疗在逆转社会恐惧方面的效果。结果显示,在条件小鼠中,与同种动物接近的物体探索、社交互动和类似小鼠的物体探索减少。灭绝训练,但不是急性地西泮治疗,可以逆转SFC诱导的行为变化。这些发现表明,社会富集环境测试为更好地了解SAD的病因提供了一种适当的行为方法。这项测试也可能对探索新的治疗方法具有重要意义。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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