Subcutaneous Injection of Bee Venom in Wistar Rats: effects on blood cells and biochemical parameters.

IF 1.2 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Pharmacopuncture Pub Date : 2022-09-30 DOI:10.3831/KPI.2022.25.3.250

Yaser Yousefpoor, Mahmoud Osanloo, Mohamad Javad Mirzaei-Parsa, Mohammad Reza Hoseini Najafabadi, Seyyed Mohammad Hashemi, Mitra Abbasifard

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引用次数: 1

Abstract

Objectives: Bee venom (BV) therapy is performed by a bee sting or subcutaneous injection of BV. However, there is not much information on the effect of BV on blood parameters after entering the body. This project aimed to assess the side effects of subcutaneous BV injections in healthy rats by measuring the hematological and biochemical parameters.

Methods: Various amounts of BV, including 100, 200, and 500 (µg/day), were subcutaneously injected into rats for 30 days. The results showed that BV affected the metabolism of the liver, kidney, and glands.

Results: An increase in blood sugar and a decrease in other biochemical parameters, including cholesterol, triglyceride, urea, creatinine AST, ALT, ALP, and phosphorous, were observed. Results also showed increased counts of white blood cells, neutrophils (%), and platelets and decreased levels of red cells, hemoglobin, and hematocrit.

Conclusion: This study demonstrates that BV therapy in medical clinics requires routine care and testing to prevent eventual metabolic and anemia side effects.

Abstract Image

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皮下注射蜂毒对Wistar大鼠血细胞及生化指标的影响。

目的:蜂毒(BV)治疗是通过蜜蜂叮咬或皮下注射BV进行的。然而，关于BV进入人体后对血液参数的影响的信息并不多。本项目旨在通过测量健康大鼠皮下注射BV的血液学和生化指标来评估其毒副作用。方法:大鼠皮下注射100、200、500不同剂量的BV(µg/d) 30 d。结果表明，BV影响肝脏、肾脏和腺体的代谢。结果:血糖升高，胆固醇、甘油三酯、尿素、肌酐、AST、ALT、ALP、磷等生化指标降低。结果还显示白细胞、中性粒细胞(%)和血小板计数增加，红细胞、血红蛋白和红细胞压积水平降低。结论:本研究表明，BV治疗需要常规护理和检测，以防止最终的代谢和贫血副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmacopuncture INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

2.10

自引率

7.10%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Pharmacopuncture covers a wide range of basic and clinical science research relevant to all aspects of the biotechnology of integrated approaches using both pharmacology and acupuncture therapeutics, including research involving pharmacology, acupuncture studies and pharmacopuncture studies. The subjects are mainly divided into three categories: pharmacology (applied phytomedicine, plant sciences, pharmacology, toxicology, medicinal plants, traditional medicines, herbal medicine, Sasang constitutional medicine, herbal formulae, foods, agricultural technologies, naturopathy, etc.), acupuncture (acupressure, electroacupuncture, laser acupuncture, moxibustion, cupping, etc.), and pharmacopuncture (aqua-acupuncture, meridian pharmacopuncture, eight-principles pharmacopuncture, animal-based pharmacopuncture, mountain ginseng pharmacopuncture, bee venom therapy, needle embedding therapy, implant therapy, etc.). Other categories include chuna treatment, veterinary acupuncture and related animal studies, alternative medicines for treating cancer and cancer-related symptoms, etc. Broader topical coverage on the effects of acupuncture, the medical plants used in traditional and alternative medicine, pharmacological action and other related modalities, such as anthroposophy, homeopathy, ayurveda, bioelectromagnetic therapy, chiropractic, neural therapy and meditation, can be considered to be within the journal’s scope if based on acupoints and meridians. Submissions of original articles, review articles, systematic reviews, case reports, brief reports, opinions, commentaries, medical lectures, letters to the editor, photo-essays, technical notes, and book reviews are encouraged. Providing free access to the full text of all current and archived articles on its website (www.journal.ac), also searchable through a Google Scholar search.