Comparison of young male mice of two different strains (C57BL/6J and the hybrid B6129SF1/J) in selected behavior tests: a small scale study.

IF 2.7 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Laboratory Animal Research Pub Date : 2022-10-02 DOI:10.1186/s42826-022-00140-5

Kristine Eraker Aasland Hansen, Alexandra M Hudecová, Fred Haugen, Eystein Skjerve, Erik Ropstad, Karin E Zimmer

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Abstract

Background: All mouse strains are different, before choosing a strain for a large study, a small scale study should be done. In this study, we compared young males of two mouse strains, C57BL/6J and the hybrid B6129SF1/J, and gained knowledge on their performance in three different behavioral tests; open field (OF) test, Barnes maze (BM) test and a restraint stress test.

Results: We found that the young males of the C57BL/6J strain spent more time moving in the OF. In the BM, the hybrid covered less ground before reaching the goal box during the first three sessions, than the C57BL/6J. The hybrid left more fecal pellets than C57BL/6J both in OF and BM. During the stress test, the C57BL/6J had a lower corticosterone response than the hybrid.

Conclusions: Our findings indicate that the C57BL/6J has a presumably higher locomotor activity and/or explorative behavior than the hybrid, while the hybrid appeared more sensitive to stress.

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两种不同品系(C57BL/6J和杂交种B6129SF1/J)的年轻雄性小鼠在选择行为试验中的比较:一项小规模研究。

背景:所有的小鼠品系都是不同的，在选择一个品系进行大规模研究之前，应该先进行小规模的研究。在本研究中，我们比较了C57BL/6J和杂交小鼠B6129SF1/J两个品系的年轻雄性小鼠，了解了它们在三种不同行为测试中的表现;开场(OF)试验、巴恩斯迷宫(BM)试验和约束应力试验。结果:我们发现C57BL/6J菌株的年轻雄性在of中活动的时间更长。在BM中，混合型在前三次训练中到达球门前的覆盖面积比C57BL/6J要少。无论在OF还是BM中，混合型均比C57BL/6J留下更多的粪便颗粒。在应激测试中，C57BL/6J对皮质酮的反应低于杂交种。结论:我们的研究结果表明，C57BL/6J可能比杂交种有更高的运动活动和/或探索行为，而杂交种对应激更敏感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Laboratory Animal Research Multiple-

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

8 weeks