Therapeutic approaches to Epstein–Barr virus cancers

IF 5.7 2区医学 Q1 VIROLOGY

Current opinion in virology Pub Date : 2022-10-01 DOI:10.1016/j.coviro.2022.101260

Samantha S Soldan, Troy E Messick, Paul M Lieberman

引用次数: 6

Abstract

Epstein–Barr virus (EBV) establishes a lifelong latent infection that can be a causal agent for a diverse spectrum of cancers and autoimmune disease. A complex and dynamic viral lifecycle evades eradication by the host immune system and confounds antiviral therapeutic strategies. To date, there are no clinically approved vaccines or therapies that selectively target EBV as the underlying cause of EBV-associated disease. Here, we review the challenges and recent advances in the development of EBV-specific therapeutics for treatment of EBV-associated cancers.

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eb病毒癌的治疗方法

eb病毒(EBV)是一种终身潜伏感染，可能是多种癌症和自身免疫性疾病的致病因子。复杂而动态的病毒生命周期逃避了宿主免疫系统的根除，并混淆了抗病毒治疗策略。迄今为止，还没有临床批准的疫苗或疗法选择性地靶向EBV作为EBV相关疾病的潜在原因。在这里，我们回顾了ebv特异性治疗治疗ebv相关癌症的挑战和最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in virology VIROLOGY-

CiteScore

11.80

自引率

5.10%

发文量

审稿时长

83 days

期刊介绍： Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.