A glimpse in post-COVID pathophysiology: the role of exhaled breath condensate pH as an early marker of residual alveolar inflammation.

IF 2.9 3区医学 Q2 RESPIRATORY SYSTEM

Expert Review of Respiratory Medicine Pub Date : 2022-10-01 Epub Date: 2022-10-05 DOI:10.1080/17476348.2022.2130764

Andrea Portacci, Paola Pierucci, Vitaliano Nicola Quaranta, Sara Quaranta, Ilaria Iorillo, Cristian Locorotondo, Enrico Buonamico, Silvano Dragonieri, Giovanna Elisiana Carpagnano

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引用次数: 1

Abstract

Background: Residual alveolar inflammation seems to be paramount in post-COVID pathophysiology. Currently, we still lack a reliable marker to detect and track alveolar phlogosis in these patients. Exhaled Breath Condensate (EBC) pH has robust evidences highlighting its correlation with lung phlogosis in various diseases. We aim to define the reliability of alveolar and bronchial EBC pH in the assessment and in the follow up of post-COVID-related inflammation.

Research design and methods: We enrolled 10 patients previously hospitalized due to COVID-19 pneumonia. We performed a complete follow-up after 3 months and 6 months from discharge. Each visit included routine blood tests, arterial blood gas analysis, 6-minute walking test, spirometry, diffusing capacity and body plethysmography. Finally, bronchial and alveolar EBC were collected at the end of each visit.

Results: Alveolar EBC pH was significantly lower than bronchial EBC pH at T1, alveolar EBC pH tended to be more acid after 3 months from hospital discharge compared to the same sample 6 months later. Serum inflammatory biomarkers showed no significant differences from T1 to T2. Alveolar EBC pH was positively correlated with neutrophil-lymphocyte ratio.

Conclusions: Collecting EBC pH could help to understand pathophysiologic mechanism as well as monitoring alveolar inflammation in the post-COVID syndrome.

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covid - 19后病理生理学的一瞥:呼气冷凝水pH值作为残留肺泡炎症的早期标志物的作用。

背景:残留的牙槽炎似乎在covid后病理生理中至关重要。目前，我们仍然缺乏一种可靠的标志物来检测和跟踪这些患者的肺泡炎。呼气冷凝水(EBC) pH值与多种疾病的肺炎相关。我们的目的是确定肺泡和支气管EBC pH值在新冠肺炎相关炎症评估和随访中的可靠性。研究设计与方法:纳入10例既往因COVID-19肺炎住院的患者。出院后3个月和6个月进行完整随访。每次就诊包括常规血液检查、动脉血气分析、6分钟步行试验、肺活量测定、弥散能力和体体积脉搏波。最后，在每次访问结束时收集支气管和肺泡EBC。结果:T1时肺泡EBC pH值明显低于支气管EBC pH值，出院后3个月肺泡EBC pH值比6个月后的肺泡EBC pH值偏酸。血清炎症生物标志物在T1和T2之间无显著差异。肺泡EBC pH值与中性粒细胞-淋巴细胞比值呈正相关。结论:采集EBC pH值有助于了解新冠肺炎后患者的病理生理机制和监测肺泡炎症。

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来源期刊

Expert Review of Respiratory Medicine RESPIRATORY SYSTEM-

CiteScore

6.80

自引率

2.60%

发文量

期刊介绍： Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity