Hisham Laswi, Bashar Attar, Robert Kwei, Michelle Ishaya, Pius Ojemolon, Bashar Natour, Mohammad Darweesh, Hafeez Shaka
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引用次数: 1
Abstract
Background: Acute pancreatitis is a common inflammatory condition that involves the pancreas. Gallstones and alcohol are the most common etiologies in the USA. Cholecystectomy is the cornerstone procedure in the management of biliary acute pancreatitis (BAP). In this study, we examined the causes and predictors of readmissions following BAP based on the procedure performed.
Methods: Using the Nationwide Readmissions Database (NRD) and the International Classification of Diseases, Tenth Revision, Clinical Modification/Procedure Coding System (ICD10-CM/PCS), we retrospectively studied BAP hospitalizations (2016 - 2018). The first hospitalization within the year was marked as index hospitalization. Index hospitalizations were categorized based on whether an endoscopic retrograde cholangiopancreatography (ERCP) and/or a cholecystectomy was performed into no procedure group, ERCP group, cholecystectomy group, and both procedures group. We subsequently identified readmissions within 30 days. Using this categorization, we studied reasons, rates, and predictors of readmissions.
Results: A total of 127,318 index hospitalizations were included. The cholecystectomy group constituted the largest share of this cohort (43.5%). Using the no procedure group as a reference, analysis of the outcomes showed that the cholecystectomy group had the lowest inpatient mortality (adjusted odds ratio (aOR): 0.18, P < 0.001), while both procedures group had the highest total hospital charges (adjusted mean difference (aMD): 42,249, P < 0.001). Acute pancreatitis without necrosis or infection was the most frequent principal diagnosis for readmission (18.7%). Analysis of readmission predictors showed that both procedures group had the lowest risk for readmission (adjusted hazard ratio (aHR): 0.40, P < 0.001). Females were less likely to be readmitted compared to males (aHR: 0.82, P < 0.001) and elderly were less likely to be readmitted compared to young adults (aHR: 0.82, P < 0.001). Patients discharged against medical advice were more likely to be readmitted (aHR: 1.76, P < 0.001).
Conclusion: Undergoing both ERCP and cholecystectomy for BAP resulted in significantly higher hospital charges with no additional mortality benefit. However, it decreased the readmission risk significantly. Acute pancreatitis without necrosis or infection was the most frequent reason for readmissions.
背景:急性胰腺炎是一种常见的累及胰腺的炎症。胆结石和酒精是美国最常见的病因。胆囊切除术是胆源性急性胰腺炎(BAP)治疗的基础手术。在这项研究中,我们根据所执行的程序检查了BAP后再入院的原因和预测因素。方法:利用全国再入院数据库(NRD)和《国际疾病分类第十版临床修改/程序编码系统》(ICD10-CM/PCS),回顾性研究2016 - 2018年BAP住院情况。年内首次住院作为指标住院。根据是否行内窥镜逆行胰胆管造影(ERCP)和/或胆囊切除术将住院指数分为无手术组、ERCP组、胆囊切除术组和两种手术组。我们随后在30天内确定了再入院人数。使用这种分类,我们研究了再入院的原因、比率和预测因素。结果:共纳入指标住院127318例。胆囊切除术组占该队列的最大份额(43.5%)。以未手术组为对照,结果分析显示,胆囊切除术组住院死亡率最低(调整优势比(aOR): 0.18, P < 0.001),两种手术组住院总费用最高(调整平均差(aMD): 42,249, P < 0.001)。无坏死或感染的急性胰腺炎是再入院最常见的主要诊断(18.7%)。再入院预测因素分析显示,两组再入院风险最低(调整风险比(aHR): 0.40, P < 0.001)。女性再入院的可能性低于男性(aHR: 0.82, P < 0.001),老年人再入院的可能性低于年轻人(aHR: 0.82, P < 0.001)。不遵医嘱出院的患者再次入院的可能性更大(aHR: 1.76, P < 0.001)。结论:接受ERCP和胆囊切除术治疗BAP的住院费用明显增加,没有额外的死亡率优势。然而,它显著降低了再入院风险。无坏死或感染的急性胰腺炎是再入院最常见的原因。