Neonatal and Maternal Risk Factors for Indirect Hyperbilirubinemia: A Cross-Sectional Study from Bahrain.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-09-09 eCollection Date: 2022-01-01 DOI:10.1155/2022/5199423

Hasan M Isa, Noor Y AlBuainain, Fatema Y Bunajem, Abdulrahman S Masood, Yusuf A Bucheery

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引用次数: 0

Abstract

Results: Out of 555 records, 404 neonates were included. Among those, 209 (51%) were males and 275 (68.1%) were Bahraini. The median indirect bilirubin level at presentation was 218 (interquartile range, 174-270) μmol/L. ABO incompatibility was the commonest risk factor for neonatal indirect hyperbilirubinemia (n = 152, 37.6%) followed by glucose-6-phosphate dehydrogenase (G6PD) deficiency (n = 130/400, 32.5%). Age (>25 years) was the commonest maternal risk factor (n = 331, 81.9%) followed by cesarean delivery (n = 137, 33.9%). Neonates with ABO incompatibility had a significantly higher mean indirect bilirubin level compared to those with other risk factors (234.9 ± 68.5 versus 225 ± 82.2 mmol/L, respectively) (P = 0.04). Phototherapy use significantly increased along with the rise of bilirubin level (P < 0.0001). Intravenous immunoglobulins (IVIG) and exchange transfusion were used in 44 (10.9%) and 14 (3.5%) patients, respectively. Neonates who received IVIG had significantly higher bilirubin levels than those who did not (P = 0.005). Male newborns (P = 0.008), Bahrainis (P = 0.001), those with reticulocytosis (P = 0.001), and those who received IVIG (P = 0.001) were more prone to have associated risk factors.

Conclusion: ABO incompatibility, G6PD deficiency, and older maternal age were the commonest neonatal and maternal risk factors for developing neonatal indirect hyperbilirubinemia. Bahraini, male newborns, reticulocytosis, and IVIG use were associated with these factors. Early detection of such factors through screening can aid in immediate management to prevent serious complications of this common condition.

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间接高胆红素血症的新生儿和产妇危险因素:来自巴林的横断面研究。

结果:555例病例中，404例新生儿入选。其中男性209人(51%)，巴林人275人(68.1%)。呈现时间接胆红素水平中位数为218 μmol/L(四分位数范围为174-270)。ABO血型不合是新生儿间接高胆红素血症最常见的危险因素(n = 152, 37.6%)，其次是葡萄糖-6-磷酸脱氢酶(G6PD)缺乏(n = 130/400, 32.5%)。年龄(>25岁)是最常见的产妇危险因素(n = 3331, 81.9%)，其次是剖宫产(n = 137, 33.9%)。ABO血型不相容新生儿的平均间接胆红素水平明显高于其他危险因素(分别为234.9±68.5和225±82.2 mmol/L) (P = 0.04)。光疗的使用随着胆红素水平的升高而显著增加(P < 0.0001)。静脉注射免疫球蛋白44例(10.9%)，换血14例(3.5%)。接受IVIG的新生儿的胆红素水平明显高于未接受IVIG的新生儿(P = 0.005)。男性新生儿(P = 0.008)、巴林人(P = 0.001)、网织红细胞增多症患者(P = 0.001)和接受IVIG的患者(P = 0.001)更容易出现相关危险因素。结论:ABO血型不合、G6PD缺乏、高龄产妇是发生新生儿间接高胆红素血症最常见的新生儿和产妇危险因素。巴林、男性新生儿、网状红细胞增多症和IVIG的使用与这些因素有关。通过筛查早期发现这些因素有助于立即进行管理，以防止这种常见疾病的严重并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.