HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse.

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
ACS Applied Electronic Materials Pub Date : 2022-12-01 Epub Date: 2022-09-19 DOI:10.1080/08916934.2022.2117307
Emma Renman, Rifat Ekici, Mia Sundström, Kristina Lejon
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引用次数: 0

Abstract

B cells have been shown to be essential for Type 1 diabetes development in the non-obese diabetic mouse, where their contribution as antigen presenting cells has been emphasised. Other important functions for B cells include surface capture of immunoglobulins and transportation of immune complexes, with subsequent endocytosis, antigen processing and antigen presentation. We have previously demonstrated that NOD B cells capture IgM and IgG immune complexes through an unknown surface molecule. In this study, we revealed the presumptive immunoglobulin-binding molecule to be HSC70. Moreover, we detected increased levels of HSC70 on NOD B cells. HSC70 has been shown to play a role in antigen processing and presentation as well as being important in several autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus. Due to its protein stabilising properties, increased HSC70 could contribute to enhanced self-antigen collection and presentation and thereby contribute to the development of Type 1 diabetes.

HSC70是NOD小鼠在B细胞上捕获免疫球蛋白的一种新的结合伙伴。
研究表明,B细胞在非肥胖糖尿病小鼠的1型糖尿病发展中起着至关重要的作用,它们作为抗原提呈细胞的作用得到了强调。B细胞的其他重要功能包括免疫球蛋白的表面捕获和免疫复合物的运输,以及随后的内吞作用、抗原加工和抗原呈递。我们之前已经证明NOD B细胞通过一种未知的表面分子捕获IgM和IgG免疫复合物。在这项研究中,我们发现推定的免疫球蛋白结合分子是HSC70。此外,我们检测到NOD B细胞上HSC70水平升高。HSC70已被证明在抗原加工和递呈中发挥作用,并在几种自身免疫性疾病中发挥重要作用,包括类风湿关节炎和系统性红斑狼疮。由于其蛋白质稳定特性,增加的HSC70可能有助于增强自身抗原的收集和呈递,从而促进1型糖尿病的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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