Platelet index on admission as a predictor of bacteremia in acute cholangitis: a 7-year retrospective observational study.

IF 2.5 3区医学 Q3 CELL BIOLOGY

Platelets Pub Date : 2022-11-17 Epub Date: 2022-09-18 DOI:10.1080/09537104.2022.2123466

XiaoYing Chen, Fu Wei, Dan Zhang, Shijing Tian

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Abstract

Bacteremia frequently occurs in patients with acute cholangitis, which could increase the risk of mortality. This single-center retrospective observational study was conducted from July 2013 to July 2020 to evaluate the predictive value of platelet index for bacteremia at admission for acute cholecystitis. A total of 285 patients with acute cholangitis were divided into bacteremia group and non-bacteremia group. The incidence of bacteremia in acute cholangitis was 48.42%. The bacteremia group had more grade III patients, higher 30d mortality rate [17(12.32%) vs 8(5.44%), p = .040] and higher incidence of thrombocytopenia [76(55.07%) vs 35(23.81%), p < .001]. Platelet counts and plateletcrit were significantly lower in the bacteremia group [84.5(60, 180) vs 162(102,225) ×10⁹/L and 0.10(0.07, 0.21)% vs 0.18(0.12, 0.25) %, both p < .001]. ROC analysis indicated a high predictive value of platelet count and plateletcrit for bacteremia in patients with acute cholangitis and the area under the ROC curve (AUC) were 0.649 and 0.655, respectively. These results support the value of platelet count and plateletcrit in early prediction of bacteremia at admission for acute cholangitis.

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入院时血小板指数作为急性胆管炎菌血症的预测指标:一项7年回顾性观察研究。

急性胆管炎患者常发生菌血症，可增加死亡风险。本研究于2013年7月至2020年7月进行单中心回顾性观察性研究，评估血小板指数对急性胆囊炎入院时菌血症的预测价值。将285例急性胆管炎患者分为菌血症组和非菌血症组。急性胆管炎中菌血症的发生率为48.42%。菌血症组III级患者较多，30d死亡率较高[17(12.32%)vs 8(5.44%)， p = 0.040]，血小板减少发生率较高[76(55.07%)vs 35(23.81%)， p = 9/L, 0.10(0.07, 0.21)% vs 0.18(0.12, 0.25) %，均p = 0.040

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来源期刊

Platelets 医学-细胞生物学

CiteScore

6.70

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： Platelets is an international, peer-reviewed journal covering all aspects of platelet- and megakaryocyte-related research. Platelets provides the opportunity for contributors and readers across scientific disciplines to engage with new information about blood platelets. The journal’s Methods section aims to improve standardization between laboratories and to help researchers replicate difficult methods. Research areas include: Platelet function Biochemistry Signal transduction Pharmacology and therapeutics Interaction with other cells in the blood vessel wall The contribution of platelets and platelet-derived products to health and disease The journal publishes original articles, fast-track articles, review articles, systematic reviews, methods papers, short communications, case reports, opinion articles, commentaries, gene of the issue, and letters to the editor. Platelets operates a single-blind peer review policy. Authors can choose to publish gold open access in this journal.