Restoration of vascular endothelial integrity by mesenchymal stromal/stem cells in debilitating virus diseases.

IF 4.3 3区生物学

Human Cell Pub Date : 2022-11-01 Epub Date: 2022-09-06 DOI:10.1007/s13577-022-00785-3

Agieshkumar Balakrishna Pillai, Vignesh Mariappan, Aashika Raagavi JeanPierre, S R Rao

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引用次数: 2

Abstract

Endothelial dysfunction is one of the key cornerstone complications of emerging and re-emerging viruses which lead to vascular leakage and a high mortality rate. The mechanism that regulates the origin of endothelial dysregulation is not completely elucidated. Currently, there are no potential pharmacological treatments and curable management for such diseases. In this sense, mesenchymal stromal/stem cells (MSCs) has been emerging to be a promising therapeutic strategy in restoring endothelial barrier function in various lung disease, including ALI and ARDS. The mechanism of the role of MSCs in restoring endothelial integrity among single-strand RNA (ssRNA) viruses that target endothelial cells remains elusive. Thus, we have discussed the therapeutic role of MSCs in restoring vascular integrity by (i) inhibiting the metalloprotease activity thereby preventing the cleavage of tight junction proteins, which are essential for maintaining membrane integrity (ii) possessing antioxidant properties which neutralize the excessive ROS production due to virus infection and its associated hyper host immune response (iii) modulating micro RNAs that regulate the endothelial activation and its integrity by downregulating the inflammatory response during ssRNA infection.

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间充质基质/干细胞在衰弱性病毒疾病中的血管内皮完整性修复

内皮功能障碍是新发和再发病毒的主要并发症之一，可导致血管渗漏和高死亡率。调控内皮细胞失调起源的机制尚未完全阐明。目前，没有潜在的药物治疗和可治愈的管理。从这个意义上说，间充质基质/干细胞(MSCs)已成为恢复各种肺部疾病(包括ALI和ARDS)内皮屏障功能的一种有前景的治疗策略。在靶向内皮细胞的单链RNA (ssRNA)病毒中，间充质干细胞在恢复内皮细胞完整性中的作用机制尚不清楚。因此，我们讨论了MSCs在恢复血管完整性方面的治疗作用，通过(i)抑制金属蛋白酶活性，从而防止紧密连接蛋白的切割;它们对维持膜完整性至关重要(ii)具有抗氧化特性，可以中和由于病毒感染及其相关的超宿主免疫反应导致的过量ROS产生(iii)在ssRNA感染期间通过下调炎症反应调节调节内皮细胞激活及其完整性的微rna。

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来源期刊

Human Cell 生物-细胞生物学

CiteScore

6.60

自引率

2.30%

发文量

176

期刊介绍： Human Cell is the official English-language journal of the Japan Human Cell Society. The journal serves as a forum for international research on all aspects of the human cell, encompassing not only cell biology but also pathology, cytology, and oncology, including clinical oncology. Embryonic stem cells derived from animals, regenerative medicine using animal cells, and experimental animal models with implications for human diseases are covered as well. Submissions in any of the following categories will be considered: Research Articles, Cell Lines, Rapid Communications, Reviews, and Letters to the Editor. A brief clinical case report focusing on cellular responses to pathological insults in human studies may also be submitted as a Letter to the Editor in a concise and short format. Not only basic scientists but also gynecologists, oncologists, and other clinical scientists are welcome to submit work expressing new ideas or research using human cells.