A Pilot Study Examining the Effects of Ischemic Conditioning on Walking Capacity and Lower Extremity Muscle Performance in Patients with Claudication.

IF 1.8 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of Vascular Research Pub Date : 2022-01-01 Epub Date: 2022-09-06 DOI:10.1159/000525166

Rory J Loo, Max V Wohlauer, Sergey S Tarima, Elizabeth Weseman, Jennifer N Nguyen, Neel A Mansukhani, Matthew J Durand

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引用次数: 0

Abstract

Introduction: This study investigated whether a novel therapy called ischemic conditioning (IC) improves walking capacity and lower extremity muscle performance in patients with peripheral vascular disease who experience intermittent claudication.

Methods: Forty-three patients with claudication were enrolled and received either IC or IC Sham for 2 weeks in this randomized, controlled, double-blinded, prospective study. IC sessions involved five cycles of alternating 5-min inflations of a blood pressure cuff to 225 mm Hg (25 mm Hg for IC Sham) and 5-min deflations, around the thigh of the affected lower extremity.

Results: There was no difference in the change in claudication onset time (Δ = 114 ± 212 s IC vs. 104 ± 173 s IC Sham; p = 0.67) or peak walking time (Δ = 42 ± 139 s IC vs. 12 ± 148 s IC Sham; p = 0.35) between the IC and IC Sham groups. At the level of the knee, participants in the IC group performed more work (Δ = 3,029 ± 4,999 J IC vs. 345 ± 2,863 J IC Sham; p = 0.03) and displayed a greater time to muscle fatigue (Δ = 147 ± 221 s IC vs. -27 ± 236 s IC Sham; p = 0.01).

Discussion/conclusion: In patients with claudication, IC improved total work performed and time to fatigue at the knee but did not change walking parameters.

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缺血性调节对跛行患者行走能力和下肢肌肉功能影响的初步研究。

摘要:本研究探讨了一种名为缺血调节(IC)的新疗法是否能改善间歇性跛行外周血管疾病患者的行走能力和下肢肌肉功能。方法:在这项随机、对照、双盲、前瞻性研究中，纳入了43例跛行患者，并接受了2周的IC或IC假手术。IC疗程包括5个循环，交替进行5分钟的血压袖带充气至225毫米汞柱(假IC为25毫米汞柱)和5分钟的减压，在受影响的下肢大腿周围进行。结果:两组的跛行发生时间变化无差异(Δ = 114±212 s与104±173 s;p = 0.67)或峰值步行时间(Δ = 42±139 s vs. 12±148 s;p = 0.35)。在膝关节水平，IC组的参与者进行了更多的工作(Δ = 3,029±4,999 J IC vs. 345±2,863 J IC Sham;p = 0.03)，肌肉疲劳时间更长(Δ = 147±221 s vs. -27±236 s;P = 0.01)。讨论/结论:在跛行患者中，IC改善了总工作量和膝盖疲劳时间，但没有改变步行参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vascular Research 医学-生理学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.